(Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetamide

Base Information

• Chemical Name: (Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetamide
• CAS No.: 944159-19-7
• Molecular Formula: C₂₂H₂₃FN₂O₂S
• Molecular Weight: 398.501

Synonyms:(Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetamide

Chemical Property of (Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetamide

Chemical Property:

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Technology Process of (Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetamide

There total 1 articles about (Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Sulindac (38194-50-2) + ethylenediamine (107-15-3,85404-18-8) → (Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetamide (944159-19-7)

Guidance literature:

Sulindac; With 1,1'-carbonyldiimidazole; In dichloromethane; for 6h; Inert atmosphere;

ethylenediamine; In dichloromethane; Inert atmosphere;

DOI:10.1016/j.bmc.2013.12.014

Reference yield: 86.0%

(Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetamide (944159-19-7) + N-((4-nitrophenoxy)carbonyl)-3-phenylsydnonimine (1446512-86-2) → N-((2-(2-((Z)-5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetamido)ethoxy)carbamoyl)-3-phenylsydnonimine

Guidance literature:

In acetonitrile; for 24h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2013.12.014

Reference yield: 75.0%

4-(2-AMINOETHYL)MORPHOLINE (2038-03-1) + (Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetamide (944159-19-7) + Sulindac (38194-50-2) → 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-N-[2-(4-morpholinyl)ethyl]-1H-indene-3-acetamide (944159-16-4) + 1,3-Dicyclohexylurea (2387-23-7)

Guidance literature:

With Succinimide; dicyclohexyl-carbodiimide; In pyridine; for 48h;

upstream raw materials:

Sulindac

ethylenediamine

Downstream raw materials:

5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-N-[2-(4-morpholinyl)ethyl]-1H-indene-3-acetamide

1,3-Dicyclohexylurea

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