2,6-Dichloro-5-[1-dimethylamino-meth-(Z)-ylidene]-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridine-3-carbaldehyde

Base Information

Chemical Name:2,6-Dichloro-5-[1-dimethylamino-meth-(Z)-ylidene]-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridine-3-carbaldehyde
CAS No.:129215-99-2
Molecular Formula:C₁₆H₁₃Cl₂F₃N₂O
Molecular Weight:377.193
Hs Code.:

Synonyms:2,6-Dichloro-5-[1-dimethylamino-meth-(Z)-ylidene]-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridine-3-carbaldehyde

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Chemical Property of 2,6-Dichloro-5-[1-dimethylamino-meth-(Z)-ylidene]-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridine-3-carbaldehyde

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Technology Process of 2,6-Dichloro-5-[1-dimethylamino-meth-(Z)-ylidene]-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridine-3-carbaldehyde

There total 6 articles about 2,6-Dichloro-5-[1-dimethylamino-meth-(Z)-ylidene]-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₀Cl₂F₃N₃⁽²⁺⁾*2Cl^(1-)

: 129215-99-2
2,6-Dichloro-5-[1-dimethylamino-meth-(Z)-ylidene]-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridine-3-carbaldehyde

Guidance literature:: With sodium acetate; In water; Yield given; Ambient temperature; 0.5-2 h;
DOI:10.1021/jo00309a026

Reference yield:

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 129215-99-2
2,6-Dichloro-5-[1-dimethylamino-meth-(Z)-ylidene]-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / piperidine / benzene / 20 h / Heating

2: 82 percent / sodium ethoxide / ethanol / 3 h / Ambient temperature

3: 78 percent / conc HCl / 20 h / Heating

4: 63 percent / NH₃ / 0.5 h / 129 - 131 °C

5: 1.) POCl₃ / 1.) rt, 3 h 2.) 1,2-dichloroethane, rt, 15 h

6: sodium acetate / H₂O / Ambient temperature; 0.5-2 h

With piperidine; hydrogenchloride; ammonia; sodium ethanolate; sodium acetate; trichlorophosphate; In ethanol; water; benzene;
DOI:10.1021/jo00309a026

Reference yield:

: 129215-95-8
4-(3-(trifluoromethyl)phenyl)glutarimide

: 129215-99-2
2,6-Dichloro-5-[1-dimethylamino-meth-(Z)-ylidene]-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) POCl₃ / 1.) rt, 3 h 2.) 1,2-dichloroethane, rt, 15 h

2: sodium acetate / H₂O / Ambient temperature; 0.5-2 h

With sodium acetate; trichlorophosphate; In water;
DOI:10.1021/jo00309a026