(S)-1-{4-[2-(4-fluorophenyl)-8-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}propan-2-ol

Base Information

Chemical Name:(S)-1-{4-[2-(4-fluorophenyl)-8-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}propan-2-ol
CAS No.:1228632-59-4
Molecular Formula:C₂₇H₂₈FN₇O
Molecular Weight:485.564
Hs Code.:

Synonyms:(S)-1-{4-[2-(4-fluorophenyl)-8-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}propan-2-ol

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Chemical Property of (S)-1-{4-[2-(4-fluorophenyl)-8-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}propan-2-ol

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Technology Process of (S)-1-{4-[2-(4-fluorophenyl)-8-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}propan-2-ol

There total 9 articles about (S)-1-{4-[2-(4-fluorophenyl)-8-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 954138-59-1
(S)-1-(piperazin-1-yl)propan-2-ol

: 1228217-19-3
6-Chloro-2-(4-fluorophenyl)-8-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1, 2-b]pyridazine

: 1228632-59-4
(S)-1-{4-[2-(4-fluorophenyl)-8-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}propan-2-ol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In pentan-1-ol; at 150 ℃; for 192h;

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1228632-59-4
(S)-1-{4-[2-(4-fluorophenyl)-8-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonia / water / 16 h / 120 °C / 7500.75 Torr / Steel reactor

1.2: 18 h / 120 °C

2.1: Iodine monochloride / chloroform; methanol / 4 h / 20 °C

3.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 18 h / Inert atmosphere; Reflux

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h

5.1: N-ethyl-N,N-diisopropylamine / pentan-1-ol / 192 h / 150 °C

With ammonia; water; Iodine monochloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; pentan-1-ol; chloroform; water;

Reference yield:

: 1228217-15-9
6-chloro-2-(4-fluorophenyl)-8-methylimidazo[1,2-b]pyridazine

: 1228632-59-4
(S)-1-{4-[2-(4-fluorophenyl)-8-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: Iodine monochloride / chloroform; methanol / 4 h / 20 °C

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 18 h / Inert atmosphere; Reflux

3: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h

4: N-ethyl-N,N-diisopropylamine / pentan-1-ol / 192 h / 150 °C

With water; Iodine monochloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; pentan-1-ol; chloroform; water;