methyl 4-(1H-2,3,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-2-oxonaphtho<2,3-b><1,4>diazepin-4-yl)benzoate

Base Information

Chemical Name:methyl 4-(1H-2,3,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-2-oxonaphtho<2,3-b><1,4>diazepin-4-yl)benzoate
CAS No.:155877-85-3
Molecular Formula:C₂₅H₂₈N₂O₃
Molecular Weight:404.509
Hs Code.:

Synonyms:methyl 4-(1H-2,3,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-2-oxonaphtho<2,3-b><1,4>diazepin-4-yl)benzoate

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Chemical Property of methyl 4-(1H-2,3,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-2-oxonaphtho<2,3-b><1,4>diazepin-4-yl)benzoate

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Technology Process of methyl 4-(1H-2,3,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-2-oxonaphtho<2,3-b><1,4>diazepin-4-yl)benzoate

There total 8 articles about methyl 4-(1H-2,3,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-2-oxonaphtho<2,3-b><1,4>diazepin-4-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 81864-05-3
2,3-diamino-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl naphthalene

: 155877-84-2
ethyl <4-(methoxycarbonyl)benzoyl>acetate

: 155877-85-3
methyl 4-(1H-2,3,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-2-oxonaphtho<2,3-b><1,4>diazepin-4-yl)benzoate

Guidance literature:: In xylene; at 140 ℃; for 1.5h;
DOI:10.1021/jm00036a017

Reference yield:

: 6223-78-5
2,5-dichloro-2,5-dimethyl hexane

: 155877-85-3
methyl 4-(1H-2,3,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-2-oxonaphtho<2,3-b><1,4>diazepin-4-yl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / AlCl₃ / CH₂Cl₂ / 0.33 h / 0 °C

2: 52 percent / KNO₃, trifluoromethanesulfonic acid / 1.5 h / Ambient temperature

3: 99 percent / 2 N aq. NaOH / ethanol / 2 h / Heating

4: 76 percent / Fe, aq. HCl / 0.5 h / 120 °C

5: 70 percent / xylene / 1.5 h / 140 °C

With hydrogenchloride; sodium hydroxide; aluminium trichloride; trifluorormethanesulfonic acid; iron; potassium nitrate; In ethanol; dichloromethane; xylene;
DOI:10.1021/jm00036a017

Reference yield:

: 7377-26-6
4-Methoxycarbonylbenzoyl chloride

: 155877-85-3
methyl 4-(1H-2,3,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-2-oxonaphtho<2,3-b><1,4>diazepin-4-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) EtONa / 1.) EtOH, 2.) EtOH, ether, 0 deg C, 1 h

2: 28percent aq. NH₃, NH₄Cl / 2 h / 55 °C

3: 70 percent / xylene / 1.5 h / 140 °C

With ammonium hydroxide; sodium ethanolate; ammonium chloride; In xylene;
DOI:10.1021/jm00036a017