1-(4,4-Bis(4-fluorophenyl)butyl)-4-(2-methoxy-3-phenylthiopropyl)piperazine

Base Information

Chemical Name:1-(4,4-Bis(4-fluorophenyl)butyl)-4-(2-methoxy-3-phenylthiopropyl)piperazine
CAS No.:143759-68-6
Molecular Formula:C₃₀H₃₆F₂N₂OS
Molecular Weight:510.691
Hs Code.:
DSSTox Substance ID:DTXSID00932019
Nikkaji Number:J1.766.507C
ChEMBL ID:CHEMBL61738

Synonyms:1-(4,4-Bis(4-fluorophenyl)butyl)-4-(2-methoxy-3-phenylthiopropyl)piperazine;Piperazine 1-(4,4-bis(4-fluorophenyl)butyl)-4-(2-methoxy-3-(phenylthio)propyl)-;143759-68-6;CHEMBL61738;C30H36F2N2OS;SCHEMBL9142362;DTXSID00932019;LS-110454;1-[4,4-Bis(4-fluorophenyl)butyl]-4-[2-methoxy-3-(phenylsulfanyl)propyl]piperazine;1-[4,4-Bis(4-fluorophenyl)butyl]-4-[2-methoxy-3-(phenylthio)propyl]piperazine

Suppliers and Price of 1-(4,4-Bis(4-fluorophenyl)butyl)-4-(2-methoxy-3-phenylthiopropyl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(4,4-Bis(4-fluorophenyl)butyl)-4-(2-methoxy-3-phenylthiopropyl)piperazine

Chemical Property:

Vapor Pressure:1.12E-14mmHg at 25°C
Boiling Point:606.9°Cat760mmHg
Flash Point:320.9°C
Density:1.19g/cm³
XLogP3:6.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:12
Exact Mass:510.25164127
Heavy Atom Count:36
Complexity:562

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(CN1CCN(CC1)CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)CSC4=CC=CC=C4

Technology Process of 1-(4,4-Bis(4-fluorophenyl)butyl)-4-(2-methoxy-3-phenylthiopropyl)piperazine

There total 4 articles about 1-(4,4-Bis(4-fluorophenyl)butyl)-4-(2-methoxy-3-phenylthiopropyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 143759-66-4
1-[4,4-bis(4-fluorophenyl)butyl]-4-(2-hydroxy-3-phenylthiopropyl)piperazine

: 74-88-4
methyl iodide

: 143759-68-6
1-[4,4-bis(4-fluorophenyl)butyl]-4-(2-methoxy-3-phenylthiopropyl)piperazine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00322-0

Reference yield:

: 108-98-5
thiophenol

: 143759-68-6
1-[4,4-bis(4-fluorophenyl)butyl]-4-(2-methoxy-3-phenylthiopropyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / ethanol

2: 38 percent / NaH / dimethylformamide

With sodium hydride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00322-0

Reference yield:

: 5631-35-6
1-[4,4-bis(4-fluorophenyl)butyl]piperazine

: 143759-68-6
1-[4,4-bis(4-fluorophenyl)butyl]-4-(2-methoxy-3-phenylthiopropyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / Bu₄NBr; aq. NaOH / CH₂Cl₂

2: 65 percent / ethanol

3: 38 percent / NaH / dimethylformamide

With sodium hydroxide; tetrabutylammomium bromide; sodium hydride; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00322-0