2-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxy]-N-propylacetamide

Base Information

Chemical Name:2-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxy]-N-propylacetamide
CAS No.:1345879-88-0
Molecular Formula:C₂₁H₂₂F₂N₂O₅
Molecular Weight:420.413
Hs Code.:

Synonyms:2-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxy]-N-propylacetamide

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Chemical Property of 2-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxy]-N-propylacetamide

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Technology Process of 2-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxy]-N-propylacetamide

There total 13 articles about 2-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxy]-N-propylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 376584-62-2
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one

: 1345882-13-4
2-(6-bromo-3-(difluoromethoxy)-2-methoxyphenoxy)-N-propylacetamide

: 1345879-88-0
2-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxy]-N-propylacetamide

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 3h; Inert atmosphere;

Reference yield:

: 99548-55-7
4-bromo-2-methyl-benzoic acid methyl ester

: 1345879-88-0
2-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxy]-N-propylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / 20 °C

2.1: ammonia / methanol / 0.17 h / 0 °C

2.2: 16 h / 20 °C

3.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

4.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 80 - 90 °C / Inert atmosphere

With N-Bromosuccinimide; ammonia; potassium acetate; caesium carbonate; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

: 78471-43-9
methyl 4-bromo-2-(bromomethyl)benzoate

: 1345879-88-0
2-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxy]-N-propylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / methanol / 0.17 h / 0 °C

1.2: 16 h / 20 °C

2.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 80 - 90 °C / Inert atmosphere

With ammonia; potassium acetate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; N,N-dimethyl-formamide;