methyl (S)-1-((S)-2-(5-(4-(6-(2-bromoacetyl) quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

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Chemical Name:methyl (S)-1-((S)-2-(5-(4-(6-(2-bromoacetyl) quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate
CAS No.:1399845-39-6
Molecular Formula:C₃₀H₃₁BrN₆O₄
Molecular Weight:619.518
Hs Code.:

Synonyms:methyl (S)-1-((S)-2-(5-(4-(6-(2-bromoacetyl) quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

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Chemical Property of methyl (S)-1-((S)-2-(5-(4-(6-(2-bromoacetyl) quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

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Technology Process of methyl (S)-1-((S)-2-(5-(4-(6-(2-bromoacetyl) quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

There total 7 articles about methyl (S)-1-((S)-2-(5-(4-(6-(2-bromoacetyl) quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1399845-38-5
methyl (S)-1-((S)-2-(5-(4-(6-(1-ethoxyvinyl)quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

: 1399845-39-6
methyl (S)-1-((S)-2-(5-(4-(6-(2-bromoacetyl) quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: With N-Bromosuccinimide; In tetrahydrofuran; water; at 0 ℃; for 1h;

Reference yield:

: 55687-02-0
6-bromo-2-chloro-quinoxaline

: 1399845-39-6
methyl (S)-1-((S)-2-(5-(4-(6-(2-bromoacetyl) quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 80 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 6 h / 80 °C / Inert atmosphere

3: N-Bromosuccinimide / water; tetrahydrofuran / 1 h / 0 °C

With N-Bromosuccinimide; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 6-bromo-2-hydroxyquinoxaline

: 1399845-39-6
methyl (S)-1-((S)-2-(5-(4-(6-(2-bromoacetyl) quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 1.5 h / 80 - 120 °C

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 80 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 6 h / 80 °C / Inert atmosphere

4: N-Bromosuccinimide / water; tetrahydrofuran / 1 h / 0 °C

With N-Bromosuccinimide; caesium carbonate; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;