2-tert-butyl 8-ethyl 6-cyano-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate

Base Information

Chemical Name:2-tert-butyl 8-ethyl 6-cyano-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate
CAS No.:1352087-68-3
Molecular Formula:C₂₂H₂₄FN₃O₄
Molecular Weight:413.449
Hs Code.:

Synonyms:2-tert-butyl 8-ethyl 6-cyano-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate

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Chemical Property of 2-tert-butyl 8-ethyl 6-cyano-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate

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Technology Process of 2-tert-butyl 8-ethyl 6-cyano-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate

There total 9 articles about 2-tert-butyl 8-ethyl 6-cyano-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189-71-5
isocyanate de chlorosulfonyle

: 1352087-62-7
2-tert-butyl 8-ethyl 7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate

: 1352087-68-3
2-tert-butyl 8-ethyl 6-cyano-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate

Guidance literature:: isocyanate de chlorosulfonyle; 2-tert-butyl 8-ethyl 7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate; In dichloromethane; at 0 - 10 ℃; for 1h; Inert atmosphere;

With N,N-dimethyl-formamide; In dichloromethane; at -10 - 20 ℃; for 5h;

Reference yield:

: 1352087-60-5
ethyl 6-chloro-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylate

: 1352087-68-3
2-tert-butyl 8-ethyl 6-cyano-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 0.5 h / 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / methanol / 0.75 h / Reflux

3.1: dichloromethane / 1 h / 0 - 10 °C / Inert atmosphere

3.2: 5 h / -10 - 20 °C

With ammonium formate; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 1352087-61-6
2-tert-butyl 8-ethyl 6-chloro-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate

: 1352087-68-3
2-tert-butyl 8-ethyl 6-cyano-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium formate / palladium 10% on activated carbon / methanol / 0.75 h / Reflux

2.1: dichloromethane / 1 h / 0 - 10 °C / Inert atmosphere

2.2: 5 h / -10 - 20 °C

With ammonium formate; palladium 10% on activated carbon; In methanol; dichloromethane;