2-(tert-butoxycarbonyl)-6-cyano-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid

Base Information

Chemical Name:2-(tert-butoxycarbonyl)-6-cyano-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid
CAS No.:1352087-69-4
Molecular Formula:C₂₀H₂₀FN₃O₄
Molecular Weight:385.395
Hs Code.:

Synonyms:2-(tert-butoxycarbonyl)-6-cyano-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(tert-butoxycarbonyl)-6-cyano-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(tert-butoxycarbonyl)-6-cyano-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid

There total 10 articles about 2-(tert-butoxycarbonyl)-6-cyano-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352087-68-3
2-tert-butyl 8-ethyl 6-cyano-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate

: 1352087-69-4
2-(tert-butoxycarbonyl)-6-cyano-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid

Guidance literature:: 2-tert-butyl 8-ethyl 6-cyano-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate; With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 60 ℃; for 24h;

With sulfuric acid; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 1352087-60-5
ethyl 6-chloro-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylate

: 1352087-69-4
2-(tert-butoxycarbonyl)-6-cyano-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 0.5 h / 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / methanol / 0.75 h / Reflux

3.1: dichloromethane / 1 h / 0 - 10 °C / Inert atmosphere

3.2: 5 h / -10 - 20 °C

4.1: water; lithium hydroxide / ethanol; tetrahydrofuran / 24 h / 60 °C

With water; ammonium formate; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 1352087-61-6
2-tert-butyl 8-ethyl 6-chloro-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate

: 1352087-69-4
2-(tert-butoxycarbonyl)-6-cyano-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium formate / palladium 10% on activated carbon / methanol / 0.75 h / Reflux

2.1: dichloromethane / 1 h / 0 - 10 °C / Inert atmosphere

2.2: 5 h / -10 - 20 °C

3.1: water; lithium hydroxide / ethanol; tetrahydrofuran / 24 h / 60 °C

With water; ammonium formate; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane;