3-chloro-4-({(1R,2R)-2-[(3R)-3-(methylamino)piperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile

Base Information

Chemical Name:3-chloro-4-({(1R,2R)-2-[(3R)-3-(methylamino)piperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile
CAS No.:1333210-19-7
Molecular Formula:C₂₂H₂₄ClN₃O
Molecular Weight:381.905
Hs Code.:

Synonyms:3-chloro-4-({(1R,2R)-2-[(3R)-3-(methylamino)piperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile

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Chemical Property of 3-chloro-4-({(1R,2R)-2-[(3R)-3-(methylamino)piperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile

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Technology Process of 3-chloro-4-({(1R,2R)-2-[(3R)-3-(methylamino)piperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile

There total 4 articles about 3-chloro-4-({(1R,2R)-2-[(3R)-3-(methylamino)piperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333210-35-7
tert-butyl {(3R)-1-[(1R,2R)-1-(2-chloro-4-cyanophenoxy)-2,3-dihydro-1H-inden-2-yl]piperidin-3-yl}carbamate

: 74-88-4
methyl iodide

: 1333210-19-7
3-chloro-4-({(1R,2R)-2-[(3R)-3-(methylamino)piperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile

Guidance literature:: tert-butyl {(3R)-1-[(1R,2R)-1-(2-chloro-4-cyanophenoxy)-2,3-dihydro-1H-inden-2-yl]piperidin-3-yl}carbamate; With water; sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

With hydrogenchloride; In 1,4-dioxane; dichloromethane;

Reference yield:

: 95-13-6
1-indene

: 1333210-19-7
3-chloro-4-({(1R,2R)-2-[(3R)-3-(methylamino)piperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hypochlorite; 4-(3-phenylpropyl)pyridine-N-oxide / (-)-chloro((1R,2R)-4,4',6,6'-tetra-tert-butyl-2,2'-[cyclohexane-1,2-diylbis(nitrilomethylidyne)]diphenolato)manganese(III) / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: acetonitrile / Reflux

3.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

4.1: sodium hydride; water / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

4.2: 0 - 20 °C

With sodium hypochlorite; di-isopropyl azodicarboxylate; water; sodium hydride; 4-(3-phenylpropyl)pyridine-N-oxide; (-)-chloro((1R,2R)-4,4',6,6'-tetra-tert-butyl-2,2'-[cyclohexane-1,2-diylbis(nitrilomethylidyne)]diphenolato)manganese(III); In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; 3.1: Mitsunobu reaction;

Reference yield:

: 768-22-9,67528-26-1,71214-81-8,85354-35-4
(1aR,6aS)-6,6a-dihydro-1aH-indeno[1,2-b]oxirene

: 1333210-19-7
3-chloro-4-({(1R,2R)-2-[(3R)-3-(methylamino)piperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / Reflux

2.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

3.1: sodium hydride; water / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

3.2: 0 - 20 °C

With di-isopropyl azodicarboxylate; water; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oil; 2.1: Mitsunobu reaction;