Technology Process of 4-methyl-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide
There total 11 articles about 4-methyl-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C27H26(2)HN5O4S2;
With
C32H64O8Rh2;
In
1,2-dichloro-ethane;
at 80 ℃;
for 2h;
Inert atmosphere;
Schlenk technique;
With
sodium cyanoborohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
for 12h;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/anie.201400881
- Guidance literature:
-
With
sodium cyanoborohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
for 12h;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/anie.201400881
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium hydroxide / dimethyl sulfoxide / 20 °C / Schlenk technique
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C / Schlenk technique
3: copper(I) thiophene-2-carboxylate / toluene / 20 °C / Schlenk technique
4: C32H64O8Rh2 / 1,2-dichloro-ethane / 2 h
/ 80 °C / Inert atmosphere; Schlenk technique
5: sodium cyanoborohydride / 1,2-dichloro-ethane / 12 h / 20 °C / Inert atmosphere; Schlenk technique
With
copper(I) thiophene-2-carboxylate; di-isopropyl azodicarboxylate; C32H64O8Rh2; sodium cyanoborohydride; triphenylphosphine; potassium hydroxide;
In
tetrahydrofuran; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;
DOI:10.1002/anie.201400881
