4-methyl-N-(prop-2-ynyl)-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide

Base Information

Chemical Name:4-methyl-N-(prop-2-ynyl)-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide
CAS No.:1623807-96-4
Molecular Formula:C₃₀H₃₁N₃O₄S₂
Molecular Weight:561.726
Hs Code.:

Synonyms:4-methyl-N-(prop-2-ynyl)-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide

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Chemical Property of 4-methyl-N-(prop-2-ynyl)-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide

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Technology Process of 4-methyl-N-(prop-2-ynyl)-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide

There total 11 articles about 4-methyl-N-(prop-2-ynyl)-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1623807-82-8
4-methyl-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide

: 106-96-7
propargyl bromide

: 1623807-96-4
4-methyl-N-(prop-2-ynyl)-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide

Guidance literature:: With potassium carbonate; In acetone; for 12h; Schlenk technique; Reflux;
DOI:10.1002/anie.201400881

Reference yield:

: 120-72-9
indole

: 1623807-96-4
4-methyl-N-(prop-2-ynyl)-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide / dimethyl sulfoxide / 20 °C / Schlenk technique

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C / Schlenk technique

3: copper(I) thiophene-2-carboxylate / toluene / 20 °C / Schlenk technique

4: C₃₂H₆₄O₈Rh₂ / 1,2-dichloro-ethane / 2 h / 80 °C / Inert atmosphere; Schlenk technique

5: sodium cyanoborohydride / 1,2-dichloro-ethane / 12 h / 20 °C / Inert atmosphere; Schlenk technique

6: potassium carbonate / acetone / 12 h / Schlenk technique; Reflux

With copper(I) thiophene-2-carboxylate; di-isopropyl azodicarboxylate; C₃₂H₆₄O₈Rh₂; sodium cyanoborohydride; potassium carbonate; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; 1,2-dichloro-ethane; acetone; toluene;
DOI:10.1002/anie.201400881

Reference yield:

: 3972-52-9
2-deuterio-1H-indole

: 1623807-96-4
4-methyl-N-(prop-2-ynyl)-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 20 °C / Schlenk technique

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C / Schlenk technique

3.1: copper(I) thiophene-2-carboxylate / toluene / 20 °C / Schlenk technique

4.1: C₃₂H₆₄O₈Rh₂ / 1,2-dichloro-ethane / 2 h / 80 °C / Inert atmosphere; Schlenk technique

4.2: 12 h / 20 °C / Inert atmosphere; Schlenk technique

5.1: potassium carbonate / acetone / 12 h / Schlenk technique; Reflux

With copper(I) thiophene-2-carboxylate; C₃₂H₆₄O₈Rh₂; potassium carbonate; triphenylphosphine; potassium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; dimethyl sulfoxide; 1,2-dichloro-ethane; acetone; toluene;
DOI:10.1002/anie.201400881