N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide

Base Information

• Chemical Name: N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide
• CAS No.: 1623807-69-1
• Molecular Formula: C₂₇H₂₇N₅O₄S₂
• Molecular Weight: 549.674
• Mol file: 1623807-69-1.mol

Synonyms:N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide

Chemical Property of N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide

There total 3 articles about N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4-toluenesulfonyl azide (941-55-9) + N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide (1623807-39-5) → N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide (1623807-69-1)

Guidance literature:

With copper(I) thiophene-2-carboxylate; In toluene; at 20 ℃; Schlenk technique;

DOI:10.1002/anie.201400881

Reference yield:

indole (120-72-9) → N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide (1623807-69-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / dimethyl sulfoxide / 20 °C / Schlenk technique

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C / Schlenk technique

3: copper(I) thiophene-2-carboxylate / toluene / 20 °C / Schlenk technique

With copper(I) thiophene-2-carboxylate; di-isopropyl azodicarboxylate; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; toluene;

DOI:10.1002/anie.201400881

Reference yield:

2-(1H-indol-1-yl)ethanol (121459-15-2) → N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide (1623807-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C / Schlenk technique

2: copper(I) thiophene-2-carboxylate / toluene / 20 °C / Schlenk technique

With copper(I) thiophene-2-carboxylate; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; toluene;

DOI:10.1002/anie.201400881

upstream raw materials:

indole

2-(1H-indol-1-yl)ethanol

4-toluenesulfonyl azide

N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

Downstream raw materials:

C₂₇H₂₇N₃O₄S₂

4-methyl-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide

4-methyl-N-(prop-2-ynyl)-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide

C₃₀H₃₁N₃O₄S₂