7-iodo-4-(2-methoxyethyl)-3-(4-(prop-2-yn-1-ylcarbamoyl)phenyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Base Information

Chemical Name:7-iodo-4-(2-methoxyethyl)-3-(4-(prop-2-yn-1-ylcarbamoyl)phenyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS No.:1383960-12-0
Molecular Formula:C₂₂H₂₀IN₃O₄
Molecular Weight:517.323
Hs Code.:

Synonyms:7-iodo-4-(2-methoxyethyl)-3-(4-(prop-2-yn-1-ylcarbamoyl)phenyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

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Chemical Property of 7-iodo-4-(2-methoxyethyl)-3-(4-(prop-2-yn-1-ylcarbamoyl)phenyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

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Technology Process of 7-iodo-4-(2-methoxyethyl)-3-(4-(prop-2-yn-1-ylcarbamoyl)phenyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

There total 2 articles about 7-iodo-4-(2-methoxyethyl)-3-(4-(prop-2-yn-1-ylcarbamoyl)phenyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1383960-04-0
tert-butyl (2-((2-(cyclohex-1-en-1-ylamino)-2-oxo-1-(4-(prop-2-yn-1-ylcarbamoyl)phenyl)ethyl)(2-methoxyethyl)carbamoyl)-4-iodophenyl)carbamate

: 1383960-12-0
7-iodo-4-(2-methoxyethyl)-3-(4-(prop-2-yn-1-ylcarbamoyl)phenyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Guidance literature:: With hydrogenchloride; acetyl chloride; In methanol; at 20 ℃; for 18h;
DOI:10.1021/ja304213w

Reference yield:

: 445479-86-7
2-[N-(tert-Butyloxycarbonyl)amino]-5-iodobenzoic acid

: 1383960-12-0
7-iodo-4-(2-methoxyethyl)-3-(4-(prop-2-yn-1-ylcarbamoyl)phenyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 0.5 h / 20 °C

1.2: 18 h / 20 °C

2.1: hydrogenchloride; acetyl chloride / methanol / 18 h / 20 °C

With hydrogenchloride; acetyl chloride; In methanol;
DOI:10.1021/ja304213w

Reference yield: 52.0%

: 201230-82-2
carbon monoxide

: 1383960-12-0
7-iodo-4-(2-methoxyethyl)-3-(4-(prop-2-yn-1-ylcarbamoyl)phenyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

: 98-80-6
phenylboronic acid

: 1383959-75-8
7-benzoyl-4-(2-methoxyethyl)-3-(4-(prop-2-yn-1-ylcarbamoyl)phenyl)-3,4-dihydro-1H-benzo[1,4]diazepine-2,5-dione

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; methoxybenzene; at 80 ℃; for 2h; under 760.051 Torr;
DOI:10.1021/ja304213w