BOC-2-AMINO-5-IODOBENZOIC ACID

Base Information

• Chemical Name: BOC-2-AMINO-5-IODOBENZOIC ACID
• CAS No.: 445479-86-7
• Molecular Formula: C12H14INO4
• Molecular Weight: 363.152
• Mol file: 445479-86-7.mol

Synonyms:2-[N-(tert-Butyloxycarbonyl)amino]-5-iodobenzoic acid;2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-iodobenzoic acid;2-[(tert-butoxycarbonyl)amino]-5-iodobenzoic acid;Benzoic acid,2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-iodo;

Chemical Property of BOC-2-AMINO-5-IODOBENZOIC ACID

Chemical Property:

• PSA: 79.12000
• LogP: 3.35000

Purity/Quality:

98%min ^*data from raw suppliers

Boc-2-amino-5-iodobenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-2-AMINO-5-IODOBENZOIC ACID

There total 1 articles about BOC-2-AMINO-5-IODOBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-5-iodobenzoic acid (5326-47-6) → 2-[N-(tert-Butyloxycarbonyl)amino]-5-iodobenzoic acid (445479-86-7)

Guidance literature:

di-tert-butyl dicarbonate; 2-amino-5-iodobenzoic acid; With sodium hydroxide; In 1,4-dioxane; water; at 20 - 50 ℃; for 22.5h;

With hydrogenchloride; In 1,4-dioxane; water; pH=4 - 5;

Reference yield: 69.0%

2-[N-(tert-Butyloxycarbonyl)amino]-5-iodobenzoic acid (445479-86-7) + methyl iodide (74-88-4) → C13H16INO4

Guidance literature:

2-[N-(tert-Butyloxycarbonyl)amino]-5-iodobenzoic acid; methyl iodide; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

With sodium hydroxide; In methanol; water; at 20 ℃; for 48h;

DOI:10.1016/j.ejmech.2020.112440

Reference yield: 67.0%

methylmagnesium bromide (75-16-1) + 2-[N-(tert-Butyloxycarbonyl)amino]-5-iodobenzoic acid (445479-86-7) → 1,1-dimethylethyl (2-acetyl-4-iodophenyl)carbamate (935292-42-5)

Guidance literature:

methylmagnesium bromide; 2-[N-(tert-Butyloxycarbonyl)amino]-5-iodobenzoic acid; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 6.08333 - 6.16667h;

With hydrogenchloride; water; In tetrahydrofuran; diethyl ether; pH=~ 6;

upstream raw materials:

di-tert-butyl dicarbonate

2-amino-5-iodobenzoic acid

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