Pte-γGlu-(Glu(1-amino-1-deoxy-D-glucitol)-Glu)2-Glu(1-amino-1-deoxy-D-glucitol)-Cys-OH

Base Information

Chemical Name:Pte-γGlu-(Glu(1-amino-1-deoxy-D-glucitol)-Glu)2-Glu(1-amino-1-deoxy-D-glucitol)-Cys-OH
CAS No.:1059477-92-7
Molecular Formula:C₆₅H₉₈N₁₆O₃₄S
Molecular Weight:1679.65
Hs Code.:

Synonyms:Pte-γGlu-(Glu(1-amino-1-deoxy-D-glucitol)-Glu)2-Glu(1-amino-1-deoxy-D-glucitol)-Cys-OH

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Chemical Property of Pte-γGlu-(Glu(1-amino-1-deoxy-D-glucitol)-Glu)2-Glu(1-amino-1-deoxy-D-glucitol)-Cys-OH

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Technology Process of Pte-γGlu-(Glu(1-amino-1-deoxy-D-glucitol)-Glu)2-Glu(1-amino-1-deoxy-D-glucitol)-Cys-OH

There total 4 articles about Pte-γGlu-(Glu(1-amino-1-deoxy-D-glucitol)-Glu)2-Glu(1-amino-1-deoxy-D-glucitol)-Cys-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: H-cys(4-methoxytrityl)-2-chlorotrityl-resin

: 125797-57-1
N¹⁰-TFA-pteroic acid

: C₂₆H₃₂N₂O₁₀

: 104091-08-9
Fmoc-Glu(OtBu)-OH

: 1059477-92-7
Pte-γGlu-(Glu(1-amino-1-deoxy-D-glucitol)-Glu)2-Glu(1-amino-1-deoxy-D-glucitol)-Cys-OH

Guidance literature:: H-cys(4-methoxytrityl)-2-chlorotrityl-resin; C₂₆H₃₂N₂O₁₀; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 1h; 2-chlorotrityl resin Inert atmosphere;

With piperidine; In N,N-dimethyl-formamide; for 0.5h; 2-chlorotrityl resin Inert atmosphere;

N¹⁰-TFA-pteroic acid; Fmoc-Glu(OtBu)-OH;

Reference yield: 51.0%

: H-cys(4-methoxytrityl)-2-chlorotrityl-resin

: 1227510-37-3
3,4;5,6-di-O-isopropylidene-1-amino-1-deoxy-(Fmoc-Glu-OH)-D-glucitol

: Fmoc-Glu-OtBu

: 37793-53-6
N¹⁰-(trifluoroacetyl)pteroic acid

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 1059477-92-7
Pte-γGlu-(Glu(1-amino-1-deoxy-D-glucitol)-Glu)2-Glu(1-amino-1-deoxy-D-glucitol)-Cys-OH

Guidance literature:: H-cys(4-methoxytrityl)-2-chlorotrityl-resin; 3,4;5,6-di-O-isopropylidene-1-amino-1-deoxy-(Fmoc-Glu-OH)-D-glucitol; Fmoc-Glu-OtBu; N¹⁰-(trifluoroacetyl)pteroic acid; Fmoc-(tBu)Asp-OH; With piperidine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; hydrazine; In dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; H-cys(4-methoxytrityl)-2-chlorotrityl-resin Inert atmosphere;

With chlorotriisopropylsilane; water; ethane-1,2-dithiol; trifluoroacetic acid; In water; Inert atmosphere;

Reference yield: 51.0%

: C₂₃H₂₂NO₂PolS

: 125797-57-1
N¹⁰-TFA-pteroic acid

: 1227510-37-3
3,4;5,6-di-O-isopropylidene-1-amino-1-deoxy-(Fmoc-Glu-OH)-D-glucitol

: 84793-07-7
Fmoc-Glu-OtBu

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 1059477-92-7
Pte-γGlu-(Glu(1-amino-1-deoxy-D-glucitol)-Glu)2-Glu(1-amino-1-deoxy-D-glucitol)-Cys-OH

Guidance literature:: C₂₃H₂₂NO₂PolS; 3,4;5,6-di-O-isopropylidene-1-amino-1-deoxy-(Fmoc-Glu-OH)-D-glucitol; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide; solid phase reaction;

N¹⁰-TFA-pteroic acid; 3,4;5,6-di-O-isopropylidene-1-amino-1-deoxy-(Fmoc-Glu-OH)-D-glucitol; Fmoc-Glu-OtBu; Fmoc-Glu(OtBu)-OH; Further stages;
DOI:10.1021/jo100448q