(S)-1-(2-Benzyloxycarbamoyl-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzylamide

Base Information

Chemical Name:(S)-1-(2-Benzyloxycarbamoyl-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzylamide
CAS No.:1026291-38-2
Molecular Formula:C₂₆H₃₃N₃O₄
Molecular Weight:451.566
Hs Code.:

Synonyms:(S)-1-(2-Benzyloxycarbamoyl-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzylamide

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Chemical Property of (S)-1-(2-Benzyloxycarbamoyl-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzylamide

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Technology Process of (S)-1-(2-Benzyloxycarbamoyl-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzylamide

There total 4 articles about (S)-1-(2-Benzyloxycarbamoyl-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87438-95-7
2-Benzyloxycarbamoyl-4-methyl-pentanoic acid

: 116774-46-0
(S)-N-Benzylpyrrolidine-2-carboxyamide

: 1026291-38-2
(S)-1-(2-Benzyloxycarbamoyl-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; for 12h;
DOI:10.1021/jm9706426

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 1026291-38-2
(S)-1-(2-Benzyloxycarbamoyl-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) MeONa, 2.) EDCl, HOBt / 1.) THF, 10 min, 2.) THF, RT, 12 h

2: 85 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 50 °C

3: HOBt, EDCl / tetrahydrofuran / 12 h / 0 - 20 °C

With sodium hydroxide; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol;
DOI:10.1021/jm9706426

Reference yield:

: 179901-13-4
2-Benzyloxycarbamoyl-4-methylpentanoic acid ethyl ester

: 1026291-38-2
(S)-1-(2-Benzyloxycarbamoyl-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 50 °C

2: HOBt, EDCl / tetrahydrofuran / 12 h / 0 - 20 °C

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol;
DOI:10.1021/jm9706426