1-(4-(8-phenyl-1-(pyridin-4-yl)-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazin-7-yl)phenyl)cyclobutanamine

Base Information

Chemical Name:1-(4-(8-phenyl-1-(pyridin-4-yl)-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazin-7-yl)phenyl)cyclobutanamine
CAS No.:1313439-55-2
Molecular Formula:C₂₉H₂₄N₆O
Molecular Weight:472.549
Hs Code.:

Synonyms:1-(4-(8-phenyl-1-(pyridin-4-yl)-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazin-7-yl)phenyl)cyclobutanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-(8-phenyl-1-(pyridin-4-yl)-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazin-7-yl)phenyl)cyclobutanamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(4-(8-phenyl-1-(pyridin-4-yl)-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazin-7-yl)phenyl)cyclobutanamine

There total 7 articles about 1-(4-(8-phenyl-1-(pyridin-4-yl)-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazin-7-yl)phenyl)cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1313441-45-0
tert-butyl (1-(4-(8-phenyl-1-(pyridin-4-yl)-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazin-7-yl)phenyl)cyclobutyl)carbamate

: 1313439-55-2
1-(4-(8-phenyl-1-(pyridin-4-yl)-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazin-7-yl)phenyl)cyclobutanamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.00833333h;

Reference yield:

: 1313440-25-3
(E)-tert-butyl (1-(4-(3-(dimethylamino)-2-phenylacryloyl)phenyl)cyclobutyl)carbamate

: 1313439-55-2
1-(4-(8-phenyl-1-(pyridin-4-yl)-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazin-7-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; methanol / 16 h / 0 - 40 °C

2.1: sodium hydroxide; dihydrogen peroxide / ethanol; water / 16 h / 20 - 50 °C

2.2: 0 °C / pH 4

3.1: sodium hydroxide; bromine / water / 24 h / 0 - 65 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

4.2: 16 h / 115 °C

5.1: Lawessons reagent / toluene / 2 h / Inert atmosphere; Reflux

6.1: xylene / 0.25 h / 150 °C / Microwave irradiation

7.1: trifluoroacetic acid / dichloromethane / 0.01 h / 20 °C

With Lawessons reagent; dihydrogen peroxide; bromine; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; xylene;

Reference yield:

: 1313440-26-4
tert-butyl (1-(4-(5-cyano-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

: 1313439-55-2
1-(4-(8-phenyl-1-(pyridin-4-yl)-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazin-7-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; dihydrogen peroxide / ethanol; water / 16 h / 20 - 50 °C

1.2: 0 °C / pH 4

2.1: sodium hydroxide; bromine / water / 24 h / 0 - 65 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

3.2: 16 h / 115 °C

4.1: Lawessons reagent / toluene / 2 h / Inert atmosphere; Reflux

5.1: xylene / 0.25 h / 150 °C / Microwave irradiation

6.1: trifluoroacetic acid / dichloromethane / 0.01 h / 20 °C

With Lawessons reagent; dihydrogen peroxide; bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; water; toluene; xylene;