Boc-L-tBuGlyΨ-L-Phe-OH

Base Information

Chemical Name:Boc-L-tBuGlyΨ-L-Phe-OH
CAS No.:214286-96-1
Molecular Formula:C₂₁H₃₁NO₅
Molecular Weight:377.481
Hs Code.:

Synonyms:Boc-L-tBuGlyΨ-L-Phe-OH

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Boc-L-tBuGlyΨ-L-Phe-OH

Chemical Property:

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Technology Process of Boc-L-tBuGlyΨ-L-Phe-OH

There total 8 articles about Boc-L-tBuGlyΨ-L-Phe-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 214286-95-0
Boc-L-tBuGlyΨ-L-Phe-OMe

: 214286-96-1
Boc-L-tBuGlyΨ-L-Phe-OH

Guidance literature:: With sodium hydroxide; In methanol; at 0 ℃; for 2h;
DOI:10.1021/jm980537b

Reference yield:

: 20859-02-3
L-tert-Leucine

: 214286-96-1
Boc-L-tBuGlyΨ-L-Phe-OH

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / 1.0 M aq. NaOH / dioxane / 18 h / 0 °C

2: 1.) LDA, 2.) 1,1'-carbonyldiimidazole / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C, 1 h

3: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₂Cl₂, 23 deg C, 24 h

4: TFA / CH₂Cl₂ / 24 h / 23 °C

5: 70 percent / H₂ / 10 percent Pd/C / methanol / 23 °C

6: 99 percent / 2.0 M NaOH / methanol / 2 h / 0 °C

With sodium hydroxide; hydrogen; sodium hydride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium diisopropyl amide; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm980537b

Reference yield:

: 62965-10-0
(S)-N-carbobenzoxy-tert-butylleucine

: 214286-96-1
Boc-L-tBuGlyΨ-L-Phe-OH

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA, 2.) 1,1'-carbonyldiimidazole / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C, 1 h

2: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₂Cl₂, 23 deg C, 24 h

3: TFA / CH₂Cl₂ / 24 h / 23 °C

4: 70 percent / H₂ / 10 percent Pd/C / methanol / 23 °C

5: 99 percent / 2.0 M NaOH / methanol / 2 h / 0 °C

With sodium hydroxide; hydrogen; sodium hydride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium diisopropyl amide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm980537b