17α-[(N-4-azido-2-nitrophenyl)aminopropyl]-3,3-dimethoxy-5α-androstan-17β-ol

Base Information

Chemical Name:17α-[(N-4-azido-2-nitrophenyl)aminopropyl]-3,3-dimethoxy-5α-androstan-17β-ol
CAS No.:300351-12-6
Molecular Formula:C₃₀H₄₅N₅O₅
Molecular Weight:555.718
Hs Code.:

Synonyms:17α-[(N-4-azido-2-nitrophenyl)aminopropyl]-3,3-dimethoxy-5α-androstan-17β-ol

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Chemical Property of 17α-[(N-4-azido-2-nitrophenyl)aminopropyl]-3,3-dimethoxy-5α-androstan-17β-ol

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Technology Process of 17α-[(N-4-azido-2-nitrophenyl)aminopropyl]-3,3-dimethoxy-5α-androstan-17β-ol

There total 5 articles about 17α-[(N-4-azido-2-nitrophenyl)aminopropyl]-3,3-dimethoxy-5α-androstan-17β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 28166-06-5
4-fluoro-3-nitrophenylazide

: 300350-96-3
3,3-(dimethoxy)-17α-aminopropyl-17β-hydroxy-5α-androstan-3-one

: 300351-12-6
17α-[(N-4-azido-2-nitrophenyl)aminopropyl]-3,3-dimethoxy-5α-androstan-17β-ol

Guidance literature:: With triethylamine; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1016/S0039-128X(00)00106-9

Reference yield:

: 846-46-8
androstanedione

: 300351-12-6
17α-[(N-4-azido-2-nitrophenyl)aminopropyl]-3,3-dimethoxy-5α-androstan-17β-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 62 percent / pTsOH*H₂O / 1 h / 40 °C

2.1: 90 percent / potassium t-butoxide / dimethylformamide / 1 h / 22 °C

3.1: LDA / tetrahydrofuran; hexane / -76 °C

3.2: 92 percent / tetrahydrofuran; hexane / 2 h / 22 °C

4.1: 69 percent / LiAlH₄ / tetrahydrofuran / 12 h / 22 °C

5.1: 47 percent / Et₃N / tetrahydrofuran; ethanol; diethyl ether

With lithium aluminium tetrahydride; potassium tert-butylate; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1016/S0039-128X(00)00106-9

Reference yield:

: 3591-19-3
3,3-(dimethoxy)-5α-androstan-17-one

: 300351-12-6
17α-[(N-4-azido-2-nitrophenyl)aminopropyl]-3,3-dimethoxy-5α-androstan-17β-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / potassium t-butoxide / dimethylformamide / 1 h / 22 °C

2.1: LDA / tetrahydrofuran; hexane / -76 °C

2.2: 92 percent / tetrahydrofuran; hexane / 2 h / 22 °C

3.1: 69 percent / LiAlH₄ / tetrahydrofuran / 12 h / 22 °C

4.1: 47 percent / Et₃N / tetrahydrofuran; ethanol; diethyl ether

With lithium aluminium tetrahydride; potassium tert-butylate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1016/S0039-128X(00)00106-9