28166-06-5Relevant academic research and scientific papers
Synthesis of Arylazide- and Diazirine-Containing CrAsH-EDT2 Photoaffinity Probes
Syeda, Shameem S.,Rice, Daren,Hook, Derek J.,Heckert, Leslie L.,Georg, Gunda I.
, p. 233 - 241 (2016)
Two photo-crosslinking biarsenical (CrAsH-EDT2)-modified probes were synthesized that are expected to be useful tools for tetracysteine-labeled proteins to facilitate the co-affinity purification of their DNA binding sequences and interacting proteins. In addition, improvements for the synthesis of CrAsH-EDT2 and N1-(4-azido-2-nitrophenyl)hexane-1,6-diamine are reported. Both photoprobes effectively entered HeLa cells (and the nucleus) and were dependent on the tetracysteine motif in recombinant DMRT1 (doublesex and Mab3-related transcription factor) to induce fluorescence, suggesting that their crosslinking abilities can be exploited for the identification of nucleic acids and proteins associated with a protein of interest.
BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING SAME
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Paragraph 00767; 00768; 00771, (2019/06/05)
Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1 ), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.
Photoaffinity labeling via nitrenium ion chemistry: Protonation of the nitrene derived from 4-amino-3-nitrophenyl azide to afford reactive nitrenium ion pairs
Voskresenska, Valentyna,Wilson, R. Marshall,Panov, Maxim,Tarnovsky, Alexander N.,Krause, Jeanette A.,Vyas, Shubham,Winter, Arthur H.,Hadad, Christopher M.
supporting information; experimental part, p. 11535 - 11547 (2011/02/25)
Phenyl azides with powerful electron-donating substituents are known to deviate from the usual photochemical behavior of other phenyl azides. They do not undergo ring expansion but form basic nitrenes that protonate to form nitrenium ions. The photochemistry of the widely used photoaffinity labeling system 4-amino-3-nitrophenyl azide, 5, has been studied by transient absorption spectroscopy from femtosecond to microsecond time domains and from a theoretical perspective. The nitrene generation from azide 5 occurs on the S2 surface, in violation of Kasha's rule. The resulting nitrene is a powerful base and abstracts protons extremely rapidly from a variety of sources to form a nitrenium ion. In methanol, this protonation occurs in about 5 ps, which is the fastest intermolecular protonation observed to date. Suitable proton sources include alcohols, amine salts, and even acidic C-H bonds such as acetonitrile. The resulting nitrenium ion is stabilized by the electron-donating 4-amino group to afford a diiminoquinone-like species that collapses relatively slowly to form the ultimate cross-linked product. In some cases in which the anion is a good hydride donor, cross-linking is replaced by reduction of the nitrenium ion to the corresponding amine.
An easy access to aryl azides from aryl amines under neutral conditions
Das, Jagattaran,Patil, Santoshkumar N.,Awasthi, Riti,Narasimhulu, C. Prasad,Trehan, Sanjay
, p. 1801 - 1806 (2007/10/03)
A variety of substituted aryl amines were transformed into aryl azides using t-BuONO and moist NaN3 in t-BuOH in good to excellent yields. Smooth transformation was observed with anilines, having electron withdrawing and donating groups. Both acid- and base-sensitive groups survived the reaction conditions. Georg Thieme Verlag Stuttgart.
SURFACE FUNCTIONALISED ADHESION
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Page/Page column 26, (2010/02/11)
The invention describes a means of enhancing the adhesion and sealant qualities of adhesives through the addition of a surface modifier. The invention has particular relevance to the adhesion and sealing of tanned leather where surface functionality suitable for effective adhesion with known adhesives is impaired by loss of functionality of the leather surface. The invention is however equally applicable to the adhesion of articles made from other materials such as plastics and plastic composites where the surface chemistry of the article requires modification for improved adhesion.
