(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenyl-methyl]pyrrolidine-1-carboxylic acid t-butyl ester

Base Information

Chemical Name:(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenyl-methyl]pyrrolidine-1-carboxylic acid t-butyl ester
CAS No.:1204677-44-0
Molecular Formula:C₂₂H₂₃Cl₂F₂NO₃
Molecular Weight:458.332
Hs Code.:

Synonyms:(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenyl-methyl]pyrrolidine-1-carboxylic acid t-butyl ester

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Chemical Property of (S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenyl-methyl]pyrrolidine-1-carboxylic acid t-butyl ester

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Technology Process of (S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenyl-methyl]pyrrolidine-1-carboxylic acid t-butyl ester

There total 3 articles about (S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenyl-methyl]pyrrolidine-1-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63418-08-6
2,6-dichloro-3,5-difluorophenol

: 1204677-43-9
1,1-dimethylethyl (3S)-3-[(S)-hydroxyphenylmethyl]-1-pyrrolidinecarboxylate

: 1204677-44-0
(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenyl-methyl]pyrrolidine-1-carboxylic acid t-butyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

Reference yield:

: 199174-24-8
tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1204677-44-0
(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenyl-methyl]pyrrolidine-1-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / 0.17 h / 0 °C

2: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / Sonication

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di-isopropyl azodicarboxylate; sodium hydrogencarbonate; triphenylphosphine; potassium bromide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmcl.2012.12.061

Reference yield:

: 191348-04-6
(S)-3-formylpyrrolidine-1-carboxylic acid t-butyl ester

: 1204677-44-0
(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenyl-methyl]pyrrolidine-1-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / Sonication

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2012.12.061