(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Base Information

Chemical Name:(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate
CAS No.:1204671-36-2
Molecular Formula:C₂HF₃O₂*C₁₇H₁₅Cl₂F₂NO
Molecular Weight:472.239
Hs Code.:

Synonyms:(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Suppliers and Price of (S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Chemical Property:

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Technology Process of (S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

There total 5 articles about (S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1204677-44-0
(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenyl-methyl]pyrrolidine-1-carboxylic acid t-butyl ester

: 76-05-1
trifluoroacetic acid

: 1204671-36-2
(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Guidance literature:: (S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenyl-methyl]pyrrolidine-1-carboxylic acid t-butyl ester; With hydrogenchloride; In ethanol; at 20 ℃; for 18h;

trifluoroacetic acid;

Reference yield:

: 1204671-35-1
(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine

: 76-05-1
trifluoroacetic acid

: 1204671-36-2
(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Guidance literature:: In water; acetonitrile;
DOI:10.1016/j.bmcl.2012.12.061

Reference yield:

: 199174-24-8
tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1204671-36-2
(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / 0.17 h / 0 °C

2: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / Sonication

4: hydrogenchloride / ethanol / 18 h / 20 °C

5: water; acetonitrile

With hydrogenchloride; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di-isopropyl azodicarboxylate; sodium hydrogencarbonate; triphenylphosphine; potassium bromide; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmcl.2012.12.061