(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine

Base Information

Chemical Name:(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine
CAS No.:1204671-35-1
Molecular Formula:C₁₇H₁₅Cl₂F₂NO
Molecular Weight:358.215
Hs Code.:

Synonyms:(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine

Chemical Property:

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Technology Process of (S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine

There total 4 articles about (S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1204677-44-0
(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenyl-methyl]pyrrolidine-1-carboxylic acid t-butyl ester

: 1204671-35-1
(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine

Guidance literature:: With hydrogenchloride; In ethanol; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2012.12.061

Reference yield:

: 199174-24-8
tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1204671-35-1
(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / 0.17 h / 0 °C

2: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / Sonication

4: hydrogenchloride / ethanol / 18 h / 20 °C

With hydrogenchloride; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di-isopropyl azodicarboxylate; sodium hydrogencarbonate; triphenylphosphine; potassium bromide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2012.12.061

Reference yield:

: 191348-04-6
(S)-3-formylpyrrolidine-1-carboxylic acid t-butyl ester

: 1204671-35-1
(S)-3-[(R)-(2,6-dichloro-3,5-difluorophenoxy)phenylmethyl]pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / Sonication

3: hydrogenchloride / ethanol / 18 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2012.12.061