cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

Base Information

Chemical Name:cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide
CAS No.:1311401-02-1
Molecular Formula:C₁₇H₁₂F₃IN₂O₃S
Molecular Weight:508.26
Hs Code.:

Synonyms:cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

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Technology Process of cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

There total 8 articles about cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1311401-77-0
1-(cyclopropylsulfonyl)-4,5-difluoro-3-(2-fluoro-4-iodophenyl)-1H-benzofuro-[6,7-d]imidazol-2(3H)-one

: 1311401-02-1
cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

Guidance literature:: With potassium trimethylsilonate; In tetrahydrofuran; at 0 - 35 ℃;

Reference yield:

: 314-41-0
1,2,3,5-tetrafluoro-4-nitrobenzene

: 1311401-02-1
cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0 - 40 °C

2.2: 0 - 20 °C

3.1: acetic acid

3.2: 0 - 40 °C

4.1: hydrogenchloride / water; tetrahydrofuran

4.2: 0 - 40 °C

5.1: dichloromethane / 20 - 40 °C

6.1: triethylamine / dichloromethane / 0 °C

6.2: 3 h / 20 - 40 °C

7.1: potassium trimethylsilonate / tetrahydrofuran / 0 - 35 °C

With hydrogenchloride; potassium trimethylsilonate; sodium hydride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; water;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1311401-02-1
cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0 - 40 °C

2.2: 0 - 20 °C

3.1: acetic acid

3.2: 0 - 40 °C

4.1: hydrogenchloride / water; tetrahydrofuran

4.2: 0 - 40 °C

5.1: dichloromethane / 20 - 40 °C

6.1: triethylamine / dichloromethane / 0 °C

6.2: 3 h / 20 - 40 °C

7.1: potassium trimethylsilonate / tetrahydrofuran / 0 - 35 °C

With hydrogenchloride; potassium trimethylsilonate; sodium hydride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; water;