2-[(4-{1-[4-(1H-tetrazol-1-yl)phenyl]-2,2-dimethylprop-1-yl}phenoxy)methyl]pyridine

Base Information

Chemical Name:2-[(4-{1-[4-(1H-tetrazol-1-yl)phenyl]-2,2-dimethylprop-1-yl}phenoxy)methyl]pyridine
CAS No.:1094060-44-2
Molecular Formula:C₂₄H₂₅N₅O
Molecular Weight:399.495
Hs Code.:

Synonyms:2-[(4-{1-[4-(1H-tetrazol-1-yl)phenyl]-2,2-dimethylprop-1-yl}phenoxy)methyl]pyridine

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Chemical Property of 2-[(4-{1-[4-(1H-tetrazol-1-yl)phenyl]-2,2-dimethylprop-1-yl}phenoxy)methyl]pyridine

Chemical Property:

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Technology Process of 2-[(4-{1-[4-(1H-tetrazol-1-yl)phenyl]-2,2-dimethylprop-1-yl}phenoxy)methyl]pyridine

There total 12 articles about 2-[(4-{1-[4-(1H-tetrazol-1-yl)phenyl]-2,2-dimethylprop-1-yl}phenoxy)methyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1094060-18-0
4-{1-[4-(pyridin-2-ylmethoxy)phenyl]-2,2-dimethylprop-1-yl}aniline

: 122-51-0
orthoformic acid triethyl ester

: 1094060-44-2
2-[(4-{1-[4-(1H-tetrazol-1-yl)phenyl]-2,2-dimethylprop-1-yl}phenoxy)methyl]pyridine

Guidance literature:: With sodium azide; acetic acid; at 95 ℃;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1094060-44-2
2-[(4-{1-[4-(1H-tetrazol-1-yl)phenyl]-2,2-dimethylprop-1-yl}phenoxy)methyl]pyridine

Guidance literature:: Multi-step reaction with 11 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0 °C

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 50 °C

2.2: 20 °C

2.3: 0.5 h

3.1: iodine; magnesium; lithium chloride / tetrahydrofuran / 50 °C

3.2: 0 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide

5.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 72 h / 760.05 Torr

6.1: Chiralpak_.(R). AD / methanol / Resolution of racemate

7.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide

8.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 55 °C

8.2: 20 °C

9.1: triethylamine; isobutyl chloroformate / acetone / 1 h / 20 °C

9.2: 0 °C

9.3: Reflux

10.1: hydrogenchloride; water / 1,4-dioxane / 0 - 20 °C

11.1: sodium azide; acetic acid / 95 °C

With hydrogenchloride; sodium azide; lithium hydroxide monohydrate; water; hydrogen; iodine; sodium carbonate; caesium carbonate; magnesium; acetic acid; triethylamine; potassium iodide; lithium chloride; isobutyl chloroformate; bis-triphenylphosphine-palladium(II) chloride; palladium hydroxide, 20 wt% on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; acetone;

Reference yield:

: 131379-16-3
4-(ethoxycarbonyl)phenylzinc iodide

: 1094060-44-2
2-[(4-{1-[4-(1H-tetrazol-1-yl)phenyl]-2,2-dimethylprop-1-yl}phenoxy)methyl]pyridine

Guidance literature:: Multi-step reaction with 11 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0 °C

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 50 °C

2.2: 20 °C

2.3: 0.5 h

3.1: iodine; magnesium; lithium chloride / tetrahydrofuran / 50 °C

3.2: 0 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide

5.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 72 h / 760.05 Torr

6.1: Chiralpak_.(R). AD / methanol / Resolution of racemate

7.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide

8.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 55 °C

8.2: 20 °C

9.1: triethylamine; isobutyl chloroformate / acetone / 1 h / 20 °C

9.2: 0 °C

9.3: Reflux

10.1: hydrogenchloride; water / 1,4-dioxane / 0 - 20 °C

11.1: sodium azide; acetic acid / 95 °C

With hydrogenchloride; sodium azide; lithium hydroxide monohydrate; water; hydrogen; iodine; sodium carbonate; caesium carbonate; magnesium; acetic acid; triethylamine; potassium iodide; lithium chloride; isobutyl chloroformate; bis-triphenylphosphine-palladium(II) chloride; palladium hydroxide, 20 wt% on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; acetone;