[(2S)-hydroxy-(1S)-[3-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]propyl]but-3-enyl][(2-nitrophenyl)sulfonyl]amine

Base Information

Chemical Name:[(2S)-hydroxy-(1S)-[3-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]propyl]but-3-enyl][(2-nitrophenyl)sulfonyl]amine
CAS No.:842166-45-4
Molecular Formula:C₂₃H₃₁N₅O₇S₂
Molecular Weight:553.66
Hs Code.:

Synonyms:[(2S)-hydroxy-(1S)-[3-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]propyl]but-3-enyl][(2-nitrophenyl)sulfonyl]amine

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Chemical Property of [(2S)-hydroxy-(1S)-[3-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]propyl]but-3-enyl][(2-nitrophenyl)sulfonyl]amine

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Technology Process of [(2S)-hydroxy-(1S)-[3-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]propyl]but-3-enyl][(2-nitrophenyl)sulfonyl]amine

There total 6 articles about [(2S)-hydroxy-(1S)-[3-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]propyl]but-3-enyl][(2-nitrophenyl)sulfonyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: C₁₇H₂₈N₄O₃S

: 842166-45-4
[(2S)-hydroxy-(1S)-[3-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]propyl]but-3-enyl][(2-nitrophenyl)sulfonyl]amine

Guidance literature:: With pyridine; triethylamine; In chloroform; at 20 ℃; for 12h;
DOI:10.1021/jm049429h

Reference yield:

: 68262-71-5,200122-85-6
Boc-Arg(MTS)-OH

: 842166-45-4
[(2S)-hydroxy-(1S)-[3-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]propyl]but-3-enyl][(2-nitrophenyl)sulfonyl]amine

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / potassium bicarbonate / dimethylformamide / 10 h / 20 °C

2: DIBAL-H / toluene; CH₂Cl₂ / 2 h / -78 °C

3: toluene; CH₂Cl₂; tetrahydrofuran / 6 h / -78 - 0 °C

4: aq. HCl; anisole / dioxane / 2 h / 20 °C

5: 3.2 g / Et₃N; pyridine / CHCl₃ / 12 h / 20 °C

With pyridine; hydrogenchloride; diisobutylaluminium hydride; potassium hydrogencarbonate; methoxybenzene; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm049429h

Reference yield:

: Boc-Arg(Mts)-NMe(OMe)

: 842166-45-4
[(2S)-hydroxy-(1S)-[3-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]propyl]but-3-enyl][(2-nitrophenyl)sulfonyl]amine

Guidance literature:: Multi-step reaction with 4 steps

1: DIBAL-H / toluene; CH₂Cl₂ / 4 h / -78 °C

2: toluene; CH₂Cl₂; tetrahydrofuran / 6 h / -78 - 0 °C

3: aq. HCl; anisole / dioxane / 2 h / 20 °C

4: 3.2 g / Et₃N; pyridine / CHCl₃ / 12 h / 20 °C

With pyridine; hydrogenchloride; diisobutylaluminium hydride; methoxybenzene; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; toluene;
DOI:10.1021/jm049429h