phenylmethyl 8-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-(5S)-[[(2-nitrophenyl)sulfonyl]amino]-(2S)-(2-naphthylmethyl)oct-3-enoate

Base Information

Chemical Name:phenylmethyl 8-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-(5S)-[[(2-nitrophenyl)sulfonyl]amino]-(2S)-(2-naphthylmethyl)oct-3-enoate
CAS No.:842166-51-2
Molecular Formula:C₄₂H₄₅N₅O₈S₂
Molecular Weight:811.98
Hs Code.:

phenylmethyl 8-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-(5S)-[[(2-nitrophenyl)sulfonyl]amino]-(2S)-(2-naphthylmethyl)oct-3-enoate

Synonyms:phenylmethyl 8-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-(5S)-[[(2-nitrophenyl)sulfonyl]amino]-(2S)-(2-naphthylmethyl)oct-3-enoate

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Chemical Property of phenylmethyl 8-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-(5S)-[[(2-nitrophenyl)sulfonyl]amino]-(2S)-(2-naphthylmethyl)oct-3-enoate

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Technology Process of phenylmethyl 8-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-(5S)-[[(2-nitrophenyl)sulfonyl]amino]-(2S)-(2-naphthylmethyl)oct-3-enoate

There total 13 articles about phenylmethyl 8-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-(5S)-[[(2-nitrophenyl)sulfonyl]amino]-(2S)-(2-naphthylmethyl)oct-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 152329-44-7
(naphthalen-2-ylmethyl)zinc(II) bromide

: C₃₂H₃₉N₅O₁₁S₃

: 842166-51-2
phenylmethyl 8-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-(5S)-[[(2-nitrophenyl)sulfonyl]amino]-(2S)-(2-naphthylmethyl)oct-3-enoate

Guidance literature:: (naphthalen-2-ylmethyl)zinc(II) bromide; In tetrahydrofuran; at 0 ℃; for 0.25h;

With boron trifluoride diethyl etherate; In tetrahydrofuran; at -78 ℃; for 0.25h;

C₃₂H₃₉N₅O₁₁S₃; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1021/jm049429h

Reference yield:

: 7396-44-3
benzyl diethylphosphonoacetate

: 842166-51-2
phenylmethyl 8-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-(5S)-[[(2-nitrophenyl)sulfonyl]amino]-(2S)-(2-naphthylmethyl)oct-3-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: DIPEA; LiCl / acetonitrile / 0.33 h / 0 °C

1.2: 1.0 g / acetonitrile / 8 h / 0 °C

2.1: CHCl₃ / 0.33 h / 20 °C

3.1: CuCN / tetrahydrofuran / 0.25 h / 0 °C

3.2: BF₃*Et₂O / tetrahydrofuran / 0.25 h / -78 °C

3.3: 408 mg / tetrahydrofuran / 1 h / -78 °C

With N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; chloroform; acetonitrile;
DOI:10.1021/jm049429h

Reference yield:

: 68262-71-5,200122-85-6
Boc-Arg(MTS)-OH

: 842166-51-2
phenylmethyl 8-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-(5S)-[[(2-nitrophenyl)sulfonyl]amino]-(2S)-(2-naphthylmethyl)oct-3-enoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: 100 percent / potassium bicarbonate / dimethylformamide / 10 h / 20 °C

2.1: DIBAL-H / toluene; CH₂Cl₂ / 2 h / -78 °C

3.1: toluene; CH₂Cl₂; tetrahydrofuran / 6 h / -78 - 0 °C

4.1: aq. HCl; anisole / dioxane / 2 h / 20 °C

5.1: 3.2 g / Et₃N; pyridine / CHCl₃ / 12 h / 20 °C

6.1: 93 percent / PPh₃; diethyl azodicarboxylate / toluene; tetrahydrofuran / 0.5 h / 20 °C

7.1: O₃ / CH₂Cl₂ / -78 °C

7.2: Me₂S / CH₂Cl₂ / 0.5 h

8.1: DIPEA; LiCl / acetonitrile / 0.33 h / 0 °C

8.2: 1.0 g / acetonitrile / 8 h / 0 °C

9.1: CHCl₃ / 0.33 h / 20 °C

10.1: CuCN / tetrahydrofuran / 0.25 h / 0 °C

10.2: BF₃*Et₂O / tetrahydrofuran / 0.25 h / -78 °C

10.3: 408 mg / tetrahydrofuran / 1 h / -78 °C

With pyridine; hydrogenchloride; diisobutylaluminium hydride; potassium hydrogencarbonate; ozone; methoxybenzene; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; acetonitrile; 6.1: Mitsunobu reaction;
DOI:10.1021/jm049429h