Nifurvidine

Base Information

• Chemical Name: Nifurvidine
• CAS No.: 1900-13-6
• Molecular Formula: C₁₁H₉N₃O₄
• Molecular Weight: 247.21
• Hs Code.: 2934999090
• Mol file: 1900-13-6.mol

Synonyms:4(1H)-Pyrimidinone,2-methyl-6-[2-(5-nitro-2-furanyl)ethenyl]- (9CI); 4-Pyrimidinol, 2-methyl-6-[2-(5-nitro-2-furyl)vinyl]-(7CI,8CI); 2-Methyl-4-[2-(5-nitro-2-furyl)vinyl]-6-pyrimidinol;2-Methyl-6-[2-(5-nitro-2-furyl)vinyl]-4-pyrimidinol; Nifurvidine

Chemical Property of Nifurvidine

Chemical Property:

• Vapor Pressure: 4.01E-07mmHg at 25°C
• Boiling Point: 415.8°Cat760mmHg
• Flash Point: 205.3°C
• PSA: 104.97000
• Density: 1.45g/cm³
• LogP: 2.68540

Purity/Quality:

98%,99%, ^*data from raw suppliers

NIFURVIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Nifurvidine

There total 11 articles about Nifurvidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-nitrofurane-2-carboxaldehyde (698-63-5) → 6-Hydroxy-2-methyl-4-<2-(5-nitro-2-furyl)-vinyl>-pyrimidin (1900-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Ac₂O / 120 - 130 °C

2: aq. HCl / ethanol / 2.5 h / (heating)

With hydrogenchloride; acetic anhydride; In ethanol;

DOI:10.1248/cpb.13.1183

Reference yield:

N-(2,6-dimethylpyrimidin-4-yl)acetamide (33721-00-5) → 6-Hydroxy-2-methyl-4-<2-(5-nitro-2-furyl)-vinyl>-pyrimidin (1900-13-6)

Guidance literature:

Multi-step reaction with 4 steps

1: Ac₂O / 150 - 155 °C

2: HNO₃ / acetic anhydride / -15 - -10 °C

3: HCl / ethanol / Heating

4: aq. HCl / ethanol / Heating

With hydrogenchloride; nitric acid; acetic anhydride; In ethanol; acetic anhydride;

DOI:10.1248/cpb.13.1183

Reference yield:

4-chloro-2-methyl-6-[2-(5-nitro-furan-2-yl)-vinyl]-pyrimidine (4592-46-5) → 6-Hydroxy-2-methyl-4-<2-(5-nitro-2-furyl)-vinyl>-pyrimidin (1900-13-6)

Guidance literature:

With hydrogenchloride; In ethanol; for 2.5h; (heating);

DOI:10.1248/cpb.13.1183

upstream raw materials:

4-chloro-2-methyl-6-[2-(5-nitro-furan-2-yl)-vinyl]-pyrimidine

2-methyl-6-[2-(5-nitro-furan-2-yl)-vinyl]-pyrimidin-4-ylamine

furfural

4-chloro-2,6-dimethylpyrimidine

Refernces