2-(methylsulfanyl)-8-phenyl-pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one

Base Information

• Chemical Name: 2-(methylsulfanyl)-8-phenyl-pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
• CAS No.: 99898-73-4
• Molecular Formula: C₁₂H₁₀N₄OS
• Molecular Weight: 258.304
• Mol file: 99898-73-4.mol

Synonyms:2-(methylsulfanyl)-8-phenyl-pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one

Chemical Property of 2-(methylsulfanyl)-8-phenyl-pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(methylsulfanyl)-8-phenyl-pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one

There total 4 articles about 2-(methylsulfanyl)-8-phenyl-pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

8-phenyl-2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one (99898-70-1) + methyl iodide (74-88-4) → 2-(methylsulfanyl)-8-phenyl-pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one (99898-73-4)

Guidance literature:

With sodium hydroxide; In ethanol;

DOI:10.1002/jhet.5570220303

Reference yield:

N-carbethoxy-N1-(4-phenyl)pyrazol-3-yl-thiourea (117411-51-5) → 2-(methylsulfanyl)-8-phenyl-pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one (99898-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 2 N NaOH; 2.) acetic acid / Ambient temperature; overnight

2: 71 percent / NaOH / aq. ethanol

With sodium hydroxide; acetic acid; In ethanol;

DOI:10.1002/jhet.5570220303

Reference yield:

4-phenyl-1H-pyrazol-3-ylamine (5591-70-8) → 2-(methylsulfanyl)-8-phenyl-pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one (99898-73-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / ethyl acetate / Ambient temperature; overnight

2: 1.) 2 N NaOH; 2.) acetic acid / Ambient temperature; overnight

3: 71 percent / NaOH / aq. ethanol

With sodium hydroxide; acetic acid; In ethanol; ethyl acetate;

DOI:10.1002/jhet.5570220303

upstream raw materials:

8-phenyl-2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one

methyl iodide

N-carbethoxy-N¹-(4-phenyl)pyrazol-3-yl-thiourea

4-phenyl-1H-pyrazol-3-ylamine

Downstream raw materials:

2-methylthio-4-n-butylamino-8-phenylpyrazolo<1,5-a>-s-triazine

4-n-butylamino-8-phenylpyrazolo<1,5-a>-s-triazine

2-methylthio-4-chloro-8-phenylpyrazolo<1,5-a>-s-triazine