1',3',3'-trimethyl-6-((4-nitrophenyl)diazenyl)spiro[chromene-2,2'-indoline]

Base Information

• Chemical Name: 1',3',3'-trimethyl-6-((4-nitrophenyl)diazenyl)spiro[chromene-2,2'-indoline]
• CAS No.: 52607-60-0
• Molecular Formula: C₂₅H₂₂N₄O₃
• Molecular Weight: 426.475
• Mol file: 52607-60-0.mol

Synonyms:1',3',3'-trimethyl-6-((4-nitrophenyl)diazenyl)spiro[chromene-2,2'-indoline]

Chemical Property of 1',3',3'-trimethyl-6-((4-nitrophenyl)diazenyl)spiro[chromene-2,2'-indoline]

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1',3',3'-trimethyl-6-((4-nitrophenyl)diazenyl)spiro[chromene-2,2'-indoline]

There total 4 articles about 1',3',3'-trimethyl-6-((4-nitrophenyl)diazenyl)spiro[chromene-2,2'-indoline] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,3,3-Trimethyl-2-methyleneindoline (118-12-7) + 5-(4-nitrophenylazo)salicylaldehyde (32041-64-8) → 1',3',3'-trimethyl-6-((4-nitrophenyl)diazenyl)spiro[chromene-2,2'-indoline] (52607-60-0)

Guidance literature:

In ethanol; Heating;

DOI:10.1002/mrc.1260301119

Reference yield:

salicylaldehyde (90-02-8) → 1',3',3'-trimethyl-6-((4-nitrophenyl)diazenyl)spiro[chromene-2,2'-indoline] (52607-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water / 1 h / 0 °C

1.2: 4 h / 20 °C

2.1: ethanol / 0.5 h / Reflux

2.2: 12 h / Inert atmosphere; Reflux

With hydrogenchloride; sodium nitrite; In ethanol; water;

DOI:10.1016/j.tetlet.2018.07.025

Reference yield:

4-nitrobenzenediazonium chloride (100-05-0) → 1',3',3'-trimethyl-6-((4-nitrophenyl)diazenyl)spiro[chromene-2,2'-indoline] (52607-60-0)

Guidance literature:

Multi-step reaction with 2 steps

2: 85 percent / ethanol / Heating

In ethanol;

DOI:10.1002/mrc.1260301119

upstream raw materials:

1,3,3-Trimethyl-2-methyleneindoline

5-(4-nitrophenylazo)salicylaldehyde

4-nitrobenzenediazonium chloride

salicylaldehyde