tert-butyl 4-(N₃-benzoylthymin-1-yl)-2S-butoxycarbonylaminobutyrate

Base Information

• Chemical Name: tert-butyl 4-(N₃-benzoylthymin-1-yl)-2S-butoxycarbonylaminobutyrate
• CAS No.: 168264-02-6
• Molecular Formula: C₂₅H₃₃N₃O₇
• Molecular Weight: 487.553
• Mol file: 168264-02-6.mol

Synonyms:tert-butyl 4-(N₃-benzoylthymin-1-yl)-2S-butoxycarbonylaminobutyrate

Chemical Property of tert-butyl 4-(N₃-benzoylthymin-1-yl)-2S-butoxycarbonylaminobutyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(N₃-benzoylthymin-1-yl)-2S-butoxycarbonylaminobutyrate

There total 2 articles about tert-butyl 4-(N₃-benzoylthymin-1-yl)-2S-butoxycarbonylaminobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-3-benzoylthymine (4330-20-5) + tert-butyl (S)-2-[(tert-butoxycarbonyl)amino]-4-bromobutanoate (163210-89-7) → tert-butyl 4-(N3-benzoylthymin-1-yl)-2S-butoxycarbonylaminobutyrate (168264-02-6)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1016/S0968-0896(00)00324-2

Reference yield:

N-tert-butoxycarbonyl glutamic acid tert-butyl ester (24277-39-2) → tert-butyl 4-(N3-benzoylthymin-1-yl)-2S-butoxycarbonylaminobutyrate (168264-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / CBrCl₃; 2-mercaptopyridine N-oxide; DCC / DMAP / tetrahydrofuran / 4 h / 0 - 20 °C / Irradiation

2: 90 percent / K₂CO₃; Cs₂CO₃; TBAI / dimethylformamide / 50 °C

With Bromotrichloromethane; tetra-(n-butyl)ammonium iodide; potassium carbonate; caesium carbonate; dicyclohexyl-carbodiimide; 2-mercaptopyridine N-oxide; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(00)00324-2

upstream raw materials:

N-3-benzoylthymine

tert-butyl (S)-2-[(tert-butoxycarbonyl)amino]-4-bromobutanoate

N-tert-butoxycarbonyl glutamic acid tert-butyl ester