2-cyclopropyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide

Base Information

Chemical Name:2-cyclopropyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide
CAS No.:164082-97-7
Molecular Formula:C₂₁H₂₃N₃O₂
Molecular Weight:349.433
Hs Code.:

Synonyms:2-cyclopropyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-cyclopropyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide

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Technology Process of 2-cyclopropyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide

There total 7 articles about 2-cyclopropyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 164082-96-6
2-cyclopropyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid methyl ester

: 164082-97-7
2-cyclopropyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide

Guidance literature:: With hydrazine; In ethanol; for 16h; Heating;
DOI:10.1021/jm960485v

Reference yield: 74.0%

: 164082-97-7
2-cyclopropyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide

Guidance literature:

Reference yield:

: 129822-42-0
N-(tert-butoxycarbonyl)-4-methoxy-2-methylaniline

: 164082-97-7
2-cyclopropyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) s-BuLi / 1.) cyclohexane, THF, -40 deg C, 0.25 h, 2.) cyclohexane, THF, from -40 deg C to RT, 2 h

2: 49 percent / CF₃COOH / CH₂Cl₂ / 72 h

3: 1.) n-BuLi, 2.) ZnCl₂

4: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 1.5 h

5: 74 percent / hydrazine / ethanol / 16 h / Heating

With n-butyllithium; sec.-butyllithium; sodium hydride; trifluoroacetic acid; zinc(II) chloride; hydrazine; In ethanol; dichloromethane;
DOI:10.1021/jm960485v