Benzoic acid (R)-1-[(2R,3R,4R,5R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-tetrahydro-furan-2-yl]-3-phenyl-prop-2-ynyl ester

Base Information

Chemical Name:Benzoic acid (R)-1-[(2R,3R,4R,5R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-tetrahydro-furan-2-yl]-3-phenyl-prop-2-ynyl ester
CAS No.:883860-02-4
Molecular Formula:C₃₃H₄₈O₆Si₂
Molecular Weight:596.912
Hs Code.:

Synonyms:Benzoic acid (R)-1-[(2R,3R,4R,5R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-tetrahydro-furan-2-yl]-3-phenyl-prop-2-ynyl ester

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Chemical Property of Benzoic acid (R)-1-[(2R,3R,4R,5R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-tetrahydro-furan-2-yl]-3-phenyl-prop-2-ynyl ester

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Technology Process of Benzoic acid (R)-1-[(2R,3R,4R,5R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-tetrahydro-furan-2-yl]-3-phenyl-prop-2-ynyl ester

There total 4 articles about Benzoic acid (R)-1-[(2R,3R,4R,5R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-tetrahydro-furan-2-yl]-3-phenyl-prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 883860-01-3
Benzoic acid (R)-1-((2S,3S,4R,5R)-3,4-dihydroxy-5-methoxy-tetrahydro-furan-2-yl)-3-phenyl-prop-2-ynyl ester

: 69739-34-0
t-butyldimethylsiyl triflate

: 883860-02-4
Benzoic acid (R)-1-[(2R,3R,4R,5R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-tetrahydro-furan-2-yl]-3-phenyl-prop-2-ynyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 3.5h;
DOI:10.1021/jo052025s

Reference yield:

: 643024-91-3
Benzoic acid (R)-1-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3-phenyl-prop-2-ynyl ester

: 883860-02-4
Benzoic acid (R)-1-[(2R,3R,4R,5R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-tetrahydro-furan-2-yl]-3-phenyl-prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / BioRad 50 WX acidic resin / methanol; tetrahydrofuran / 19 h / 70 °C

2: 96 percent / 2,6-lutidine / CH₂Cl₂ / 3.5 h / 0 °C

With 2,6-dimethylpyridine; BioRad 50 WX acidic resin; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo052025s

Reference yield:

: 98-88-4
benzoyl chloride

: 883860-02-4
Benzoic acid (R)-1-[(2R,3R,4R,5R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-tetrahydro-furan-2-yl]-3-phenyl-prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / 4-DMAP; triethylamine / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 53 percent / BioRad 50 WX acidic resin / methanol; tetrahydrofuran / 19 h / 70 °C

3: 96 percent / 2,6-lutidine / CH₂Cl₂ / 3.5 h / 0 °C

With 2,6-dimethylpyridine; dmap; BioRad 50 WX acidic resin; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo052025s