3-isopropylaminomethyl-5-trifluoromethylbenzoic acid

Base Information

Chemical Name:3-isopropylaminomethyl-5-trifluoromethylbenzoic acid
CAS No.:1018473-28-3
Molecular Formula:C₁₂H₁₄F₃NO₂
Molecular Weight:261.244
Hs Code.:

Synonyms:3-isopropylaminomethyl-5-trifluoromethylbenzoic acid

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Chemical Property of 3-isopropylaminomethyl-5-trifluoromethylbenzoic acid

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Technology Process of 3-isopropylaminomethyl-5-trifluoromethylbenzoic acid

There total 4 articles about 3-isopropylaminomethyl-5-trifluoromethylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1018473-27-2
ethyl 3-isopropylaminomethyl-5-trifluoromethylbenzoate

: 1018473-28-3
3-isopropylaminomethyl-5-trifluoromethylbenzoic acid

Guidance literature:: ethyl 3-isopropylaminomethyl-5-trifluoromethylbenzoate; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; water; pH=4 - 5;

Reference yield:

: 1018473-24-9
3-bromo-5-trifluoromethyl-benzoic acid ethyl ester

: 1018473-28-3
3-isopropylaminomethyl-5-trifluoromethylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 18 h / 90 °C

2.1: ozone / methanol / 1.5 h / -78 °C

2.2: 3 h / -78 - 20 °C

3.1: acetic acid / ethanol / 2 h / 50 °C / Sealed vessel

3.2: 2.5 h / 0 - 20 °C / Sealed vessel

4.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

4.2: pH 4 - 5

With lithium hydroxide; water; ozone; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol;

Reference yield:

: 328-67-6
3-bromo-5-(trifluoromethyl)benzoic acid

: 1018473-28-3
3-isopropylaminomethyl-5-trifluoromethylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 20 - 90 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 18 h / 90 °C

3.1: ozone / methanol / 1.5 h / -78 °C

3.2: 3 h / -78 - 20 °C

4.1: acetic acid / ethanol / 2 h / 50 °C / Sealed vessel

4.2: 2.5 h / 0 - 20 °C / Sealed vessel

5.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

5.2: pH 4 - 5

With lithium hydroxide; water; ozone; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; In tetrahydrofuran; methanol; ethanol;