3-(isopropylaminomethyl)-N-(4-methyl-3-(3-methyl-1-(6-methylaminopyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-trifluoromethylbenzamide

Base Information

Chemical Name:3-(isopropylaminomethyl)-N-(4-methyl-3-(3-methyl-1-(6-methylaminopyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-trifluoromethylbenzamide
CAS No.:1018471-71-0
Molecular Formula:C₂₈H₃₁F₃N₈O
Molecular Weight:552.602
Hs Code.:

Synonyms:3-(isopropylaminomethyl)-N-(4-methyl-3-(3-methyl-1-(6-methylaminopyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-trifluoromethylbenzamide

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Chemical Property of 3-(isopropylaminomethyl)-N-(4-methyl-3-(3-methyl-1-(6-methylaminopyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-trifluoromethylbenzamide

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Technology Process of 3-(isopropylaminomethyl)-N-(4-methyl-3-(3-methyl-1-(6-methylaminopyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-trifluoromethylbenzamide

There total 7 articles about 3-(isopropylaminomethyl)-N-(4-methyl-3-(3-methyl-1-(6-methylaminopyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1018473-28-3
3-isopropylaminomethyl-5-trifluoromethylbenzoic acid

: 1018473-31-8
6-methyl-N₁-(3-methyl-1-(6-methylaminopyrimidin-4-yl)-1H-pyrazol-5-yl)benzen-1,3-diamine

: 1018471-71-0
3-(isopropylaminomethyl)-N-(4-methyl-3-(3-methyl-1-(6-methylaminopyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-trifluoromethylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 328-67-6
3-bromo-5-(trifluoromethyl)benzoic acid

: 1018471-71-0
3-(isopropylaminomethyl)-N-(4-methyl-3-(3-methyl-1-(6-methylaminopyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 20 - 90 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 18 h / 90 °C

3.1: ozone / methanol / 1.5 h / -78 °C

3.2: 3 h / -78 - 20 °C

4.1: acetic acid / ethanol / 2 h / 50 °C / Sealed vessel

4.2: 2.5 h / 0 - 20 °C / Sealed vessel

5.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

5.2: pH 4 - 5

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

With lithium hydroxide; water; ozone; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1018473-22-7
C₈H₈ClN₅

: 1018471-71-0
3-(isopropylaminomethyl)-N-(4-methyl-3-(3-methyl-1-(6-methylaminopyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: water; isopropyl alcohol / 4 h / 50 °C / Sealed tube

2: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 48 h / 120 °C / High-pressure tube

3: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;