(2R)-3-[(tert-butoxycarbonyl)amino]-2-[2-(tert-butoxycarbonyl)oxy-5-chlorobenzyl]propanoic acid

Base Information

Chemical Name:(2R)-3-[(tert-butoxycarbonyl)amino]-2-[2-(tert-butoxycarbonyl)oxy-5-chlorobenzyl]propanoic acid
CAS No.:1312771-21-3
Molecular Formula:C₂₀H₂₈ClNO₇
Molecular Weight:429.898
Hs Code.:

Synonyms:(2R)-3-[(tert-butoxycarbonyl)amino]-2-[2-(tert-butoxycarbonyl)oxy-5-chlorobenzyl]propanoic acid

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Chemical Property of (2R)-3-[(tert-butoxycarbonyl)amino]-2-[2-(tert-butoxycarbonyl)oxy-5-chlorobenzyl]propanoic acid

Chemical Property:

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Technology Process of (2R)-3-[(tert-butoxycarbonyl)amino]-2-[2-(tert-butoxycarbonyl)oxy-5-chlorobenzyl]propanoic acid

There total 1 articles about (2R)-3-[(tert-butoxycarbonyl)amino]-2-[2-(tert-butoxycarbonyl)oxy-5-chlorobenzyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 889857-60-7
(2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

: 1312771-21-3
(2R)-3-[(tert-butoxycarbonyl)amino]-2-[2-(tert-butoxycarbonyl)oxy-5-chlorobenzyl]propanoic acid

Guidance literature:: (2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid; With boron tribromide; In dichloromethane; at 20 ℃; Cooling with ice;

With water; sodium hydroxide; In dichloromethane; Cooling with ice;

Reference yield:

: 1312771-21-3
(2R)-3-[(tert-butoxycarbonyl)amino]-2-[2-(tert-butoxycarbonyl)oxy-5-chlorobenzyl]propanoic acid

: 623-33-6
glycine ethyl ester hydrochloride

: 1312771-22-4
ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 35 ℃; for 1.5h;

Reference yield:

: 1312771-21-3
(2R)-3-[(tert-butoxycarbonyl)amino]-2-[2-(tert-butoxycarbonyl)oxy-5-chlorobenzyl]propanoic acid

: 1312771-25-7
(6R)-6-(5-chloro-2-cyanobenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1.5 h / 35 °C

2.1: methanesulfonic acid / ethanol / 6 h / 40 °C

2.2: Cooling with ice

3.1: triethylamine; sodium tris(acetoxy)borohydride / ethanol / 3.5 h / 20 °C / Cooling with ice

3.2: Cooling with ice

4.1: sodium hydroxide; water / 4 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; acetonitrile / 21 h / 40 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

7.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

With methanesulfonic acid; water; sodium tris(acetoxy)borohydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;