(6R)-6-[5-chloro-2-(trifluoromethanesulfonyl)oxybenzyl]-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

Base Information

Chemical Name:(6R)-6-[5-chloro-2-(trifluoromethanesulfonyl)oxybenzyl]-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione
CAS No.:1312771-26-8
Molecular Formula:C₂₃H₂₄ClF₃N₂O₈S
Molecular Weight:580.966
Hs Code.:

Synonyms:(6R)-6-[5-chloro-2-(trifluoromethanesulfonyl)oxybenzyl]-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

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Chemical Property of (6R)-6-[5-chloro-2-(trifluoromethanesulfonyl)oxybenzyl]-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

Chemical Property:

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Technology Process of (6R)-6-[5-chloro-2-(trifluoromethanesulfonyl)oxybenzyl]-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

There total 6 articles about (6R)-6-[5-chloro-2-(trifluoromethanesulfonyl)oxybenzyl]-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17763-80-3
para-nitrophenyl triflate

: 1312771-20-2
(6R)-6-(5-chloro-2-hydroxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

: 1312771-26-8
(6R)-6-[5-chloro-2-(trifluoromethanesulfonyl)oxybenzyl]-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 889857-60-7
(2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

: 1312771-26-8
(6R)-6-[5-chloro-2-(trifluoromethanesulfonyl)oxybenzyl]-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron tribromide / dichloromethane / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1.5 h / 35 °C

3.1: methanesulfonic acid / ethanol / 6 h / 40 °C

3.2: Cooling with ice

4.1: triethylamine; sodium tris(acetoxy)borohydride / ethanol / 3.5 h / 20 °C / Cooling with ice

4.2: Cooling with ice

5.1: sodium hydroxide; water / 4 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; acetonitrile / 21 h / 40 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With methanesulfonic acid; water; boron tribromide; sodium tris(acetoxy)borohydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1312771-22-4
ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate

: 1312771-26-8
(6R)-6-[5-chloro-2-(trifluoromethanesulfonyl)oxybenzyl]-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanesulfonic acid / ethanol / 6 h / 40 °C

1.2: Cooling with ice

2.1: triethylamine; sodium tris(acetoxy)borohydride / ethanol / 3.5 h / 20 °C / Cooling with ice

2.2: Cooling with ice

3.1: sodium hydroxide; water / 4 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; acetonitrile / 21 h / 40 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With methanesulfonic acid; water; sodium tris(acetoxy)borohydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; acetonitrile;