ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate

Base Information

Chemical Name:ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate
CAS No.:1312771-22-4
Molecular Formula:C₂₄H₃₅ClN₂O₈
Molecular Weight:515.004
Hs Code.:

Synonyms:ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate

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Chemical Property of ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate

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Technology Process of ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate

There total 2 articles about ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312771-21-3
(2R)-3-[(tert-butoxycarbonyl)amino]-2-[2-(tert-butoxycarbonyl)oxy-5-chlorobenzyl]propanoic acid

: 623-33-6
glycine ethyl ester hydrochloride

: 1312771-22-4
ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 35 ℃; for 1.5h;

Reference yield:

: 889857-60-7
(2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

: 1312771-22-4
ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron tribromide / dichloromethane / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1.5 h / 35 °C

With boron tribromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

Reference yield:

: 1312771-22-4
ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate

: C₁₄H₁₉ClN₂O₄

Guidance literature:: ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate; With methanesulfonic acid; In ethanol; at 40 ℃; for 6h;

In ethanol; Cooling with ice;