diethyl 2,6-dimethyl-4-(4-(trifluoromethyl)phenyl)-pyridine-3,5-dicarboxylate

Base Information

Chemical Name:diethyl 2,6-dimethyl-4-(4-(trifluoromethyl)phenyl)-pyridine-3,5-dicarboxylate
CAS No.:1204601-40-0
Molecular Formula:C₂₀H₂₀F₃NO₄
Molecular Weight:395.378
Hs Code.:

Synonyms:diethyl 2,6-dimethyl-4-(4-(trifluoromethyl)phenyl)-pyridine-3,5-dicarboxylate

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Chemical Property of diethyl 2,6-dimethyl-4-(4-(trifluoromethyl)phenyl)-pyridine-3,5-dicarboxylate

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Technology Process of diethyl 2,6-dimethyl-4-(4-(trifluoromethyl)phenyl)-pyridine-3,5-dicarboxylate

There total 4 articles about diethyl 2,6-dimethyl-4-(4-(trifluoromethyl)phenyl)-pyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 23118-51-6
2,6-dimethyl-4-(4-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

: 1204601-40-0
diethyl 2,6-dimethyl-4-(4-(trifluoromethyl)phenyl)-pyridine-3,5-dicarboxylate

Guidance literature:: With dihydrogen peroxide; sodium iodide; In acetic acid; at 20 ℃; for 0.333333h;
DOI:10.1007/BF03246562

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1204601-40-0
diethyl 2,6-dimethyl-4-(4-(trifluoromethyl)phenyl)-pyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / ethanol / 78 °C

2: sodium chlorite; hydrogenchloride / ethanol; water / 20 °C

With hydrogenchloride; ammonium hydroxide; sodium chlorite; In ethanol; water; 1: |Hantzsch Dihydropyridine Synthesis;
DOI:10.1016/j.tetlet.2016.05.061

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1204601-40-0
diethyl 2,6-dimethyl-4-(4-(trifluoromethyl)phenyl)-pyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / ethanol / 78 °C

2: sodium chlorite; hydrogenchloride / ethanol; water / 20 °C

With hydrogenchloride; ammonium hydroxide; sodium chlorite; In ethanol; water; 1: |Hantzsch Dihydropyridine Synthesis;
DOI:10.1016/j.tetlet.2016.05.061