3-(benzylamino)-2-methyl-3-phenyl-2-((trimethylsilyl)methyl)propan-1-ol

Base Information

• Chemical Name: 3-(benzylamino)-2-methyl-3-phenyl-2-((trimethylsilyl)methyl)propan-1-ol
• CAS No.: 1198587-76-6
• Molecular Formula: C₂₁H₃₁NOSi
• Molecular Weight: 341.569

Synonyms:3-(benzylamino)-2-methyl-3-phenyl-2-((trimethylsilyl)methyl)propan-1-ol

Chemical Property of 3-(benzylamino)-2-methyl-3-phenyl-2-((trimethylsilyl)methyl)propan-1-ol

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 3-(benzylamino)-2-methyl-3-phenyl-2-((trimethylsilyl)methyl)propan-1-ol

There total 2 articles about 3-(benzylamino)-2-methyl-3-phenyl-2-((trimethylsilyl)methyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C7H15OSi(1-)*Li(1+) + N-benzylidene benzylamine (780-25-6) → N-benzyl-1-phenyl-3-((trimethylsilyl)methyl)but-3-en-1-amine (1198587-77-7) + 3-(benzylamino)-2-methyl-3-phenyl-2-((trimethylsilyl)methyl)propan-1-ol (1198587-76-6)

Guidance literature:

N-benzylidene benzylamine; With titanium(IV) isopropylate; cyclopentylmagnesium chloride; In diethyl ether; at -78 ℃; for 1.5h; Inert atmosphere;

C₇H₁₅OSi^(1-)*Li⁽¹⁺⁾; In tetrahydrofuran; diethyl ether; hexane; at -78 - 20 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ja908504z

Reference yield:

N-benzylidene benzylamine (780-25-6) + 2-(trimethylsilylmethyl)prop-2-en-1-ol (81302-80-9) → N-benzyl-1-phenyl-3-((trimethylsilyl)methyl)but-3-en-1-amine (1198587-77-7) + 3-(benzylamino)-2-methyl-3-phenyl-2-((trimethylsilyl)methyl)propan-1-ol (1198587-76-6)

Guidance literature:

N-benzylidene benzylamine; With titanium(IV) isopropylate; cyclopentylmagnesium chloride; In diethyl ether; at -78 ℃; for 1.5h; Inert atmosphere;

2-(trimethylsilylmethyl)prop-2-en-1-ol; With n-butyllithium; In tetrahydrofuran; diethyl ether; Petroleum ether; at -78 - 0 ℃; for 14h; Inert atmosphere;

With sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; petroelum ether; water; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2010.11.059

Reference yield: 70.0%

3-(benzylamino)-2-methyl-3-phenyl-2-((trimethylsilyl)methyl)propan-1-ol (1198587-76-6) → (3S,4S,9aS)-3-methyl-4-phenyl-3-((trimethylsilyl)methyl)octahydropyrido[2,1-b][1,3]oxazine + (3R,4S,9aS)-3-methyl-4-phenyl-3-((trimethylsilyl)methyl)octahydropyrido[2,1-b][1,3]oxazine

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.11.059

upstream raw materials:

N-benzylidene benzylamine

2-(trimethylsilylmethyl)prop-2-en-1-ol

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