5-chloro-N-{1-[(3-cyanophenyl)methyl]-4-(methoxy)-1H-indazole-3-yl}-2-thiophene sulphonamide

Base Information

• Chemical Name: 5-chloro-N-{1-[(3-cyanophenyl)methyl]-4-(methoxy)-1H-indazole-3-yl}-2-thiophene sulphonamide
• CAS No.: 1240518-03-9
• Molecular Formula: C₂₀H₁₅ClN₄O₃S₂
• Molecular Weight: 458.949
• Mol file: 1240518-03-9.mol

Synonyms:5-chloro-N-{1-[(3-cyanophenyl)methyl]-4-(methoxy)-1H-indazole-3-yl}-2-thiophene sulphonamide

Chemical Property of 5-chloro-N-{1-[(3-cyanophenyl)methyl]-4-(methoxy)-1H-indazole-3-yl}-2-thiophene sulphonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-N-{1-[(3-cyanophenyl)methyl]-4-(methoxy)-1H-indazole-3-yl}-2-thiophene sulphonamide

There total 3 articles about 5-chloro-N-{1-[(3-cyanophenyl)methyl]-4-(methoxy)-1H-indazole-3-yl}-2-thiophene sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-chlorothien-2-ylsulfonyl chloride (2766-74-7) + 3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile (1240518-02-8) → 5-chloro-N-{1-[(3-cyanophenyl)methyl]-4-(methoxy)-1H-indazole-3-yl}-2-thiophene sulphonamide (1240518-03-9)

Guidance literature:

With pyridine; at 20 ℃; Inert atmosphere;

Reference yield:

2-fluoro-6-methoxybenzonitrile (94088-46-7) → 5-chloro-N-{1-[(3-cyanophenyl)methyl]-4-(methoxy)-1H-indazole-3-yl}-2-thiophene sulphonamide (1240518-03-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrazine hydrate / butan-1-ol / 18 h / Reflux; Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

2.2: 0.33 h / Inert atmosphere

3.1: pyridine / 0.67 h / 20 °C / Inert atmosphere

With pyridine; hydrazine hydrate; potassium hydroxide; In dimethyl sulfoxide; butan-1-ol;

Reference yield:

4-(methyloxy)-1H-indazol-3-amine (886362-07-8) → 5-chloro-N-{1-[(3-cyanophenyl)methyl]-4-(methoxy)-1H-indazole-3-yl}-2-thiophene sulphonamide (1240518-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

1.2: 0.33 h / Inert atmosphere

2.1: pyridine / 0.67 h / 20 °C / Inert atmosphere

With pyridine; potassium hydroxide; In dimethyl sulfoxide;

upstream raw materials:

5-chlorothien-2-ylsulfonyl chloride

3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile

2-fluoro-6-methoxybenzonitrile

4-(methyloxy)-1H-indazol-3-amine

Downstream raw materials:

2-{[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate

C₂₃H₂₃ClN₄O₄S₂

(3S)-N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide hydrochloride

(3R)-N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide hydrochloride