ethyl 1-(4-((6-(2-methyl-1,3-dioxolan-2-yl)hex-2-yn-1-yl)oxy)phenyl)hydrazine-1-carboxylate

Base Information

Chemical Name:ethyl 1-(4-((6-(2-methyl-1,3-dioxolan-2-yl)hex-2-yn-1-yl)oxy)phenyl)hydrazine-1-carboxylate
CAS No.:1505447-91-5
Molecular Formula:C₁₉H₂₆N₂O₅
Molecular Weight:362.426
Hs Code.:

Synonyms:ethyl 1-(4-((6-(2-methyl-1,3-dioxolan-2-yl)hex-2-yn-1-yl)oxy)phenyl)hydrazine-1-carboxylate

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Chemical Property of ethyl 1-(4-((6-(2-methyl-1,3-dioxolan-2-yl)hex-2-yn-1-yl)oxy)phenyl)hydrazine-1-carboxylate

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Technology Process of ethyl 1-(4-((6-(2-methyl-1,3-dioxolan-2-yl)hex-2-yn-1-yl)oxy)phenyl)hydrazine-1-carboxylate

There total 5 articles about ethyl 1-(4-((6-(2-methyl-1,3-dioxolan-2-yl)hex-2-yn-1-yl)oxy)phenyl)hydrazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1505447-83-5
2-(6-(4-iodophenoxy)hex-4-yn-1-yl)-2-methyl-1,3-dioxolane

: 4114-31-2
ethylhydrazine carboxylate

: 1505447-91-5
ethyl 1-(4-((6-(2-methyl-1,3-dioxolan-2-yl)hex-2-yn-1-yl)oxy)phenyl)hydrazine-1-carboxylate

Guidance literature:: With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h; Sealed tube; Inert atmosphere;
DOI:10.1021/ol4031638

Reference yield:

: 24400-75-7
ethylene-cetal de la bromo-5 pentanone-2

: 1505447-91-5
ethyl 1-(4-((6-(2-methyl-1,3-dioxolan-2-yl)hex-2-yn-1-yl)oxy)phenyl)hydrazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 5 h / -78 - 0 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C

3.1: triethylamine / dichloromethane / 1 h / 0 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

5.1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Sealed tube; Inert atmosphere

With copper(l) iodide; n-butyllithium; 1,10-Phenanthroline; tetrabutyl ammonium fluoride; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol4031638

Reference yield:

: C₁₆H₃₀O₃Si

: 1505447-91-5
ethyl 1-(4-((6-(2-methyl-1,3-dioxolan-2-yl)hex-2-yn-1-yl)oxy)phenyl)hydrazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C

2: triethylamine / dichloromethane / 1 h / 0 °C

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

4: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Sealed tube; Inert atmosphere

With copper(l) iodide; 1,10-Phenanthroline; tetrabutyl ammonium fluoride; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol4031638