3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-methylpropanoic acid

Base Information

Chemical Name:3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-methylpropanoic acid
CAS No.:1312009-32-7
Molecular Formula:C₂₂H₂₁ClN₄O₄
Molecular Weight:440.886
Hs Code.:

Synonyms:3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-methylpropanoic acid

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Chemical Property of 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-methylpropanoic acid

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Technology Process of 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-methylpropanoic acid

There total 15 articles about 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312008-97-1
methyl 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-methylpropanoate

: 1312009-32-7
3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-methylpropanoic acid

Guidance literature:: methyl 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-methylpropanoate; With water; sodium hydroxide; In ethanol; at 85 ℃; Inert atmosphere;

With hydrogenchloride; In ethanol; water; for 1h; Sonographic reaction;

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1312009-32-7
3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

2.1: sodium hydroxide / methanol / 20 °C

2.2: pH 1 - 2 / Acidic conditions

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

4.1: triethylamine / acetonitrile / 0 °C / Inert atmosphere; Reflux

5.1: caesium carbonate / N,N-dimethyl-formamide / 20 - 80 °C / Inert atmosphere

6.1: sodium hydroxide; water / ethanol / 85 °C / Inert atmosphere

6.2: 1 h / Sonographic reaction

With oxalyl dichloride; water; potassium carbonate; caesium carbonate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1312009-32-7
3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2.1: triethylamine / acetonitrile / 0 °C / Inert atmosphere; Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 20 - 80 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol / 85 °C / Inert atmosphere

4.2: 1 h / Sonographic reaction

With oxalyl dichloride; water; caesium carbonate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;