4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure-tert.butylester

Base Information

Chemical Name:4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure-tert.butylester
CAS No.:86768-13-0
Molecular Formula:C₂₂H₂₀ClFN₂O₃
Molecular Weight:414.864
Hs Code.:

Synonyms:4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure-tert.butylester

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Chemical Property of 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure-tert.butylester

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Technology Process of 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure-tert.butylester

There total 7 articles about 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure-tert.butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.2%

: 86768-12-9
4-(4-Chlorbenzoyl)-3-diazoacetyl-1-(4-fluorphenyl)-pyrazol

: 75-65-0
tert-butyl alcohol

: 86768-13-0
4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure-tert.butylester

Guidance literature:: With N-ethylmorpholine;; silver benzoate; for 1h; Irradiation;
DOI:10.1002/ardp.19833160706

Reference yield:

: 67382-35-8,28587-05-5
(2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one

: 86768-13-0
4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure-tert.butylester

Guidance literature:: Multi-step reaction with 5 steps

1: 51.4 percent / Et₃N / CHCl₃ / Ambient temperature

2: 92.6 percent / NaOH

3: 93.7 percent / SOCl₂ / CHCl₃ / 3 h / Heating

4: 79.2 percent / 1,2-dimethoxy-ethane; diethyl ether / 96 h / 0 °C

5: 76.2 percent / N-ethylmorpholine, silver benzoate / 1 h / Irradiation

With N-ethylmorpholine;; sodium hydroxide; thionyl chloride; silver benzoate; triethylamine; In 1,2-dimethoxyethane; diethyl ether; chloroform;
DOI:10.1002/ardp.19833160706

Reference yield:

: 99-91-2
para-chloroacetophenone

: 86768-13-0
4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure-tert.butylester

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / 2 h

2: 51.4 percent / Et₃N / CHCl₃ / Ambient temperature

3: 92.6 percent / NaOH

4: 93.7 percent / SOCl₂ / CHCl₃ / 3 h / Heating

5: 79.2 percent / 1,2-dimethoxy-ethane; diethyl ether / 96 h / 0 °C

6: 76.2 percent / N-ethylmorpholine, silver benzoate / 1 h / Irradiation

With N-ethylmorpholine;; sodium hydroxide; thionyl chloride; silver benzoate; triethylamine; In 1,2-dimethoxyethane; diethyl ether; chloroform;
DOI:10.1002/ardp.19833160706