4-(4-Chlorbenzoyl)-3-diazoacetyl-1-(4-fluorphenyl)-pyrazol

Base Information

• Chemical Name: 4-(4-Chlorbenzoyl)-3-diazoacetyl-1-(4-fluorphenyl)-pyrazol
• CAS No.: 86768-12-9
• Molecular Formula: C₁₈H₁₀ClFN₄O₂
• Molecular Weight: 368.754
• Mol file: 86768-12-9.mol

Synonyms:4-(4-Chlorbenzoyl)-3-diazoacetyl-1-(4-fluorphenyl)-pyrazol

Chemical Property of 4-(4-Chlorbenzoyl)-3-diazoacetyl-1-(4-fluorphenyl)-pyrazol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-Chlorbenzoyl)-3-diazoacetyl-1-(4-fluorphenyl)-pyrazol

There total 6 articles about 4-(4-Chlorbenzoyl)-3-diazoacetyl-1-(4-fluorphenyl)-pyrazol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.2%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeurechlorid (86768-11-8) → 4-(4-Chlorbenzoyl)-3-diazoacetyl-1-(4-fluorphenyl)-pyrazol (86768-12-9)

Guidance literature:

In 1,2-dimethoxyethane; diethyl ether; at 0 ℃; for 96h;

DOI:10.1002/ardp.19833160706

Reference yield:

(2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one (67382-35-8,28587-05-5) → 4-(4-Chlorbenzoyl)-3-diazoacetyl-1-(4-fluorphenyl)-pyrazol (86768-12-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 51.4 percent / Et₃N / CHCl₃ / Ambient temperature

2: 92.6 percent / NaOH

3: 93.7 percent / SOCl₂ / CHCl₃ / 3 h / Heating

4: 79.2 percent / 1,2-dimethoxy-ethane; diethyl ether / 96 h / 0 °C

With sodium hydroxide; thionyl chloride; triethylamine; In 1,2-dimethoxyethane; diethyl ether; chloroform;

DOI:10.1002/ardp.19833160706

Reference yield:

para-chloroacetophenone (99-91-2) → 4-(4-Chlorbenzoyl)-3-diazoacetyl-1-(4-fluorphenyl)-pyrazol (86768-12-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / 2 h

2: 51.4 percent / Et₃N / CHCl₃ / Ambient temperature

3: 92.6 percent / NaOH

4: 93.7 percent / SOCl₂ / CHCl₃ / 3 h / Heating

5: 79.2 percent / 1,2-dimethoxy-ethane; diethyl ether / 96 h / 0 °C

With sodium hydroxide; thionyl chloride; triethylamine; In 1,2-dimethoxyethane; diethyl ether; chloroform;

DOI:10.1002/ardp.19833160706

upstream raw materials:

diazomethane

4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeurechlorid

(2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one

para-chloroacetophenone

Downstream raw materials:

4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure-tert.butylester

4-(4-Chlorbenzyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure

4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure

4-(4-Chlor-α-hydroxy-benzyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure