N-[(Z)-1-[5-chloro-2-(methylamino)phenyl]-2,2-dimethylpropylidene]-2-methyl-(R(S))-2-propanesulfinamide

Base Information

Chemical Name:N-[(Z)-1-[5-chloro-2-(methylamino)phenyl]-2,2-dimethylpropylidene]-2-methyl-(R(S))-2-propanesulfinamide
CAS No.:1287718-22-2
Molecular Formula:C₁₆H₂₅ClN₂OS
Molecular Weight:328.906
Hs Code.:

Synonyms:N-[(Z)-1-[5-chloro-2-(methylamino)phenyl]-2,2-dimethylpropylidene]-2-methyl-(R(S))-2-propanesulfinamide

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Chemical Property of N-[(Z)-1-[5-chloro-2-(methylamino)phenyl]-2,2-dimethylpropylidene]-2-methyl-(R(S))-2-propanesulfinamide

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Technology Process of N-[(Z)-1-[5-chloro-2-(methylamino)phenyl]-2,2-dimethylpropylidene]-2-methyl-(R(S))-2-propanesulfinamide

There total 5 articles about N-[(Z)-1-[5-chloro-2-(methylamino)phenyl]-2,2-dimethylpropylidene]-2-methyl-(R(S))-2-propanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1287718-07-3
1-[5-chloro-2-(methylamino)phenyl]-2,2-dimethyl-1-propanone

: 196929-78-9
(R)-2-methylpropane-2-sulfinamide

: 1287718-22-2
N-[(Z)-1-[5-chloro-2-(methylamino)phenyl]-2,2-dimethylpropylidene]-2-methyl-(R(S))-2-propanesulfinamide

Guidance literature:: 1-[5-chloro-2-(methylamino)phenyl]-2,2-dimethyl-1-propanone; (R)-2-methylpropane-2-sulfinamide; With titanium(IV) tetraethanolate; at 75 ℃; for 12h; Inert atmosphere;

With water; sodium chloride; In ethyl acetate; for 0.166667h;
DOI:10.1021/jo1025767

Reference yield:

: 1313017-13-8
N-[4-chloro-2-(2,2-dimethyl-1-oxopropyl)phenyl]-2,2-dimethylpropanamide

: 1287718-22-2
N-[(Z)-1-[5-chloro-2-(methylamino)phenyl]-2,2-dimethylpropylidene]-2-methyl-(R(S))-2-propanesulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

1.2: 5 h

2.1: hydrogenchloride; water / 12 h / 90 °C

3.1: titanium(IV) tetraethanolate / 12 h / 75 °C / Inert atmosphere

3.2: 0.17 h

With hydrogenchloride; titanium(IV) tetraethanolate; water; sodium hydride; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo1025767

Reference yield:

: 65854-91-3
N-(4-chlorophenyl)-2,2-dimethylpropionamide

: 1287718-22-2
N-[(Z)-1-[5-chloro-2-(methylamino)phenyl]-2,2-dimethylpropylidene]-2-methyl-(R(S))-2-propanesulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 2 h / -10 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: 5 h

3.1: hydrogenchloride; water / 12 h / 90 °C

4.1: titanium(IV) tetraethanolate / 12 h / 75 °C / Inert atmosphere

4.2: 0.17 h

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; water; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo1025767