N-[4-chloro-2-(2,2-dimethyl-1-oxopropyl)phenyl]-N,2,2-trimethylpropanamide

Base Information

Chemical Name:N-[4-chloro-2-(2,2-dimethyl-1-oxopropyl)phenyl]-N,2,2-trimethylpropanamide
CAS No.:1313017-14-9
Molecular Formula:C₁₇H₂₄ClNO₂
Molecular Weight:309.836
Hs Code.:

Synonyms:N-[4-chloro-2-(2,2-dimethyl-1-oxopropyl)phenyl]-N,2,2-trimethylpropanamide

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Chemical Property of N-[4-chloro-2-(2,2-dimethyl-1-oxopropyl)phenyl]-N,2,2-trimethylpropanamide

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Technology Process of N-[4-chloro-2-(2,2-dimethyl-1-oxopropyl)phenyl]-N,2,2-trimethylpropanamide

There total 2 articles about N-[4-chloro-2-(2,2-dimethyl-1-oxopropyl)phenyl]-N,2,2-trimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1313017-13-8
N-[4-chloro-2-(2,2-dimethyl-1-oxopropyl)phenyl]-2,2-dimethylpropanamide

: 74-88-4
methyl iodide

: 1313017-14-9
N-[4-chloro-2-(2,2-dimethyl-1-oxopropyl)phenyl]-N,2,2-trimethylpropanamide

Guidance literature:: N-[4-chloro-2-(2,2-dimethyl-1-oxopropyl)phenyl]-2,2-dimethylpropanamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; for 5h;
DOI:10.1021/jo1025767

Reference yield:

: 65854-91-3
N-(4-chlorophenyl)-2,2-dimethylpropionamide

: 1313017-14-9
N-[4-chloro-2-(2,2-dimethyl-1-oxopropyl)phenyl]-N,2,2-trimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 2 h / -10 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: 5 h

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo1025767