3,3′-(phenylmethylene)-bis-indole-((1-benzyl-1,2,3-triazol-4-yl)methyl)

Base Information

• Chemical Name: 3,3′-(phenylmethylene)-bis-indole-((1-benzyl-1,2,3-triazol-4-yl)methyl)
• CAS No.: 1174761-01-3
• Molecular Formula: C₄₃H₃₆N₈
• Molecular Weight: 664.812
• Mol file: 1174761-01-3.mol

Synonyms:3,3′-(phenylmethylene)-bis-indole-((1-benzyl-1,2,3-triazol-4-yl)methyl)

Chemical Property of 3,3′-(phenylmethylene)-bis-indole-((1-benzyl-1,2,3-triazol-4-yl)methyl)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3′-(phenylmethylene)-bis-indole-((1-benzyl-1,2,3-triazol-4-yl)methyl)

There total 3 articles about 3,3′-(phenylmethylene)-bis-indole-((1-benzyl-1,2,3-triazol-4-yl)methyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

indole (120-72-9) + benzaldehyde (100-52-7) + propargyl bromide (106-96-7) + benzyl azide (622-79-7) → 3,3′-(phenylmethylene)-bis-indole-((1-benzyl-1,2,3-triazol-4-yl)methyl) (1174761-01-3)

Guidance literature:

indole; benzaldehyde; With silica-gel-supported sulfuric acid; iodine; In acetonitrile; at 20 ℃;

propargyl bromide; With potassium hydroxide; In acetonitrile; at 20 ℃; for 1h;

benzyl azide; With copper(l) iodide; triethylamine; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1021/acs.joc.8b02056

Reference yield: 85.0%

indole (120-72-9) + benzyl bromide (100-39-0) + benzaldehyde (100-52-7) + propargyl bromide (106-96-7) → 3,3′-(phenylmethylene)-bis-indole-((1-benzyl-1,2,3-triazol-4-yl)methyl) (1174761-01-3)

Guidance literature:

indole; benzaldehyde; With silica-gel-supported sulfuric acid; iodine; In acetonitrile; at 20 ℃;

propargyl bromide; With potassium hydroxide; at 20 ℃; for 1h;

benzyl bromide; With copper(l) iodide; sodium azide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/acs.joc.8b02056

Reference yield: 80.0%

3,3'-(phenylmethylene)bis(1-prop-2-yn-1-yl-1H-indole) (1174760-91-8) + benzyl bromide (100-39-0) → 3,3′-(phenylmethylene)-bis-indole-((1-benzyl-1,2,3-triazol-4-yl)methyl) (1174761-01-3)

Guidance literature:

With copper(l) iodide; sodium azide; In polyethylene glycol-400; at 20 ℃; for 6h; regioselective reaction;

DOI:10.1016/j.bmcl.2009.04.131

upstream raw materials:

3,3'-(phenylmethylene)bis(1-prop-2-yn-1-yl-1H-indole)

benzyl bromide

indole

benzaldehyde