5,10-ethano-5,10-dideazaaminopterin

Base Information

Chemical Name:5,10-ethano-5,10-dideazaaminopterin
CAS No.:137465-07-7
Molecular Formula:C23H24 N6 O5
Molecular Weight:464.47386
Hs Code.:
Mol file:137465-07-7.mol

Synonyms:Pyrimido[4,5-c]isoquinoline,L-glutamic acid deriv.

Suppliers and Price of 5,10-ethano-5,10-dideazaaminopterin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5,10-ethano-5,10-dideazaaminopterin

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：195.87000
Density:1.475g/cm³
LogP:1.76060

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5,10-ethano-5,10-dideazaaminopterin

There total 15 articles about 5,10-ethano-5,10-dideazaaminopterin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 137465-06-6
5,10-ethano-5,10-dideazaaminopterin diethyl ester

: 137465-07-7
5,10-ethano-5,10-dideazaaminopterin

Guidance literature:: With sodium hydroxide; In 2-methoxy-ethanol; for 4h; Ambient temperature;
DOI:10.1021/jm00080a017

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 137465-07-7
5,10-ethano-5,10-dideazaaminopterin

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) n-BuLi / 1.) THF, hexane, -100 deg C to -95 deg C, 10 min, 2.) THF, hexane, -100 deg C to -95 deg C, 10 min

2: 94 percent / aq. NaOH / 2-methoxy-ethanol / 15 h / Heating

3: HCl conc. / 4 h / Heating

4: 39 percent / H₂, HCl conc. / Pd / dioxane / 20 h / 40 - 48 °C

5: 1.) NaH, 2.) KH / 1.) THF, reflux, 2.) THF, reflux, 2 h

6: 82 percent / diphenyl ether / 4 h / 190 - 205 °C

7: 56 percent / BH₃*THF / tetrahydrofuran / 16 h / Ambient temperature

8: 61 percent / DDQ / acetic acid / 18 h / Ambient temperature

9: 80 percent / 10percent NaOH / 2-methoxy-ethanol / 18 h / Ambient temperature

10: 1.) Et₃N, isobutyl chloroformate / 1.) DMSO, 1.5 h, 2.) DMSO, RT, 22 h

11: 73 percent / NaOH / 2-methoxy-ethanol / 4 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; n-butyllithium; borane-THF; hydrogen; potassium hydride; sodium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; isobutyl chloroformate; palladium; In tetrahydrofuran; 1,4-dioxane; diphenylether; 2-methoxy-ethanol; acetic acid;
DOI:10.1021/jm00080a017

Reference yield:

: 623-00-7
4-bromobenzenecarbonitrile

: 137465-07-7
5,10-ethano-5,10-dideazaaminopterin

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) n-BuLi / 1.) THF, hexane, -100 deg C to -95 deg C, 10 min, 2.) THF, hexane, -100 deg C to -95 deg C, 10 min

2: 94 percent / aq. NaOH / 2-methoxy-ethanol / 15 h / Heating

3: HCl conc. / 4 h / Heating

4: 39 percent / H₂, HCl conc. / Pd / dioxane / 20 h / 40 - 48 °C

5: 1.) NaH, 2.) KH / 1.) THF, reflux, 2.) THF, reflux, 2 h

6: 82 percent / diphenyl ether / 4 h / 190 - 205 °C

7: 56 percent / BH₃*THF / tetrahydrofuran / 16 h / Ambient temperature

8: 61 percent / DDQ / acetic acid / 18 h / Ambient temperature

9: 80 percent / 10percent NaOH / 2-methoxy-ethanol / 18 h / Ambient temperature

10: 1.) Et₃N, isobutyl chloroformate / 1.) DMSO, 1.5 h, 2.) DMSO, RT, 22 h

11: 73 percent / NaOH / 2-methoxy-ethanol / 4 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; n-butyllithium; borane-THF; hydrogen; potassium hydride; sodium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; isobutyl chloroformate; palladium; In tetrahydrofuran; 1,4-dioxane; diphenylether; 2-methoxy-ethanol; acetic acid;
DOI:10.1021/jm00080a017